Anti-Human ZAP-70, FITC (Clone:1E7.2)检测试剂

ZAP70 分子靶点信息概述

• 分子名：ZAP70, zeta chain of T cell receptor associated protein kinase 70
• 基因家族：SH2 domain containing; Syk family tyrosine kinases
• 别名：ZAP-70; STD
• 曾用名：SRK
• 全称：tyrosine-protein kinase ZAP-70; SRK

ZAP70 分子靶点综述

TCR 相关蛋白-70，在 T 细胞和 NK 细胞中表达，是 TCR信号传递和发育所必需的。ZAP-70 通过与 TCR 复合物不变亚基中存在的 ITAMs 结合，与 TCR 复合物相互作用。激活后，ZAP-70通过两种机制在几个酪氨酸残基上磷酸化：自磷酸化和 Src 家族酪氨酸激酶Lck1-3的反式磷酸化。酪氨酸磷酸化 ZAP-70 与其增加激酶活性有关，并触发下游信号事件。虽然 ZAP-70 通常在T 细胞和 NK 细胞中表达，但最近的几项研究也显示 ZAP-70 阳性表达与突变 IgVH 在 B 慢性淋巴细胞白血病(CCL)中的表达高度相关。总之，ZAP-70 的表达可以通过细胞内流式细胞术来测量，可以作为 B-CLL 的预后指标。

人 Human ZAP70 分子靶点信息

• 分子名：ZAP70, zeta chain of T cell receptor associated protein kinase 70
• 别称：
  • 70 kDa zeta-associated protein
  • 70 kDa zeta-chain associated protein
  • ADMIO2
  • FLJ17670
  • FLJ17679
  • IMD48
  • SRK
  • STCD
  • STD
  • syk-related tyrosine kinase
  • tyrosine-protein kinase ZAP-70
  • TZK
  • ZAP-70
  • zeta chain of T cell receptor associated protein kinase 70kDa
  • zeta chain of T-cell receptor associated protein kinase 70
  • zeta-chain (TCR) associated protein kinase 70kDa
  • zeta-chain associated protein kinase, 70kD
• 基因序列：NCBI_Gene: 7535
• 蛋白序列：UniProtKB: P43403

人 Human ZAP70靶点分子功能（预测）

Enables non-membrane spanning protein tyrosine kinase activity and phosphotyrosine residue binding activity. Involved in immune response and protein phosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; and positive thymic T cell selection. Located in plasma membrane. Part of T cell receptor complex. Colocalizes with membrane raft. Implicated in immunodeficiency 48 and severe combined immunodeficiency.