F21FP302

Anti-Mouse FoxP3, PE (Clone:3G3)流式抗体 (新品)

¥720.00 – ¥1,584.00

说明书

分子靶点：FOXP3, IPEX
种属：小鼠 (Mouse)
标记：PE
亚型：Mouse IgG1, κ
克隆号：3G3

在售SKU, 70-AM0F04-20, 70-AM0F04-50, 70-AM0F04-100, AM0F04, 70-F21FP302-25, 70-F21FP302-100

文章目录[隐藏]

分子信息
FOXP3 分子靶点信息概述
FOXP3 分子靶点综述
- 小鼠 Mouse Foxp3 分子靶点信息
- 小鼠 Mouse Foxp3 靶点分子功能（预测）

商品名	Anti-Mouse FoxP3, PE (Clone:3G3)流式抗体
靶点	FOXP3, IPEX
标记	PE
仪器	适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	3G3
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

分子信息

概述小鼠 FOXP3, IPEX 靶点信息

FOXP3 分子靶点信息概述

分子名：FOXP3, forkhead box P3
基因家族：Forkhead boxes
别名：JM2; XPID; AIID; PIDX; DIETER; SCURFIN
曾用名：IPEX
全称：immune dysregulation, polyendocrinopathy, enteropathy, X-linked

FOXP3 分子靶点综述

FoxP3蛋白是转录因子叉头家族的成员之一，表达于调节性T细胞(Regulatory T Cells, Treg)，其发育和功能受到叉头蛋白的影响。T细胞中FoxP3的异常表达会抑制其活性和细胞因子分泌。

小鼠 Mouse Foxp3 分子靶点信息

分子名：Foxp3, forkhead box P3
别称：
- JM2
- scurfin
- scurfy
- sf
基因序列：NCBI_Gene: 20371
蛋白序列：

小鼠 Mouse Foxp3 靶点分子功能（预测）

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; and regulation of T cell anergy. Acts upstream of or within several processes, including positive regulation of T cell tolerance induction; regulation of T cell activation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).