F1111702

Anti-Human CD117, PE(Clone：104D2) (新品)

¥952.00 – ¥2,112.00

说明书

分子靶点：KIT, CD117, SCFR
种属：人 (Human)
标记：PE
亚型：Mouse IgG1, κ
克隆号：104D2

在售SKU, 70-AH11704-20, 70-AH11704-50, 70-AH11704-100, AH11704, 70-F1111702-25, 70-F1111702-100

文章目录[隐藏]

结果示例
分子信息
KIT 分子靶点信息概述
KIT 分子靶点综述
- 人 Human KIT 分子靶点信息
- 人 Human KIT靶点分子功能（预测）

商品名	Anti-Human CD117, PE(Clone：104D2)
靶点	KIT, CD117, SCFR
标记	PE
仪器	适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	104D2
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

结果示例

图 - TF-1 细胞用 Anti-Human CD117, PE (F1111702)(实线) 和 Mouse IgG1 κ Isotype Control, PE(CMG104) (虚线)染色的结果。以 TF-1 活细胞设门进行分析。

分子信息

概述人 KIT, CD117, SCFR 靶点信息

KIT 分子靶点信息概述

分子名：KIT, KIT proto-oncogene, receptor tyrosine kinase
基因家族：Receptor tyrosine kinases; CD molecules; Immunoglobulin like domain containing
别名：CD117; SCFR; C-Kit
曾用名：PBT
全称：mast/stem cell growth factor receptor Kit; piebald trait; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

KIT 分子靶点综述

CD117 也称为 c-Kit、Steel 因子受体和干细胞因子受体，这种酪氨酸激酶蛋白主要表达于造血祖细胞、肥大细胞、急性髓系白血病细胞(AML)。CD117 激活促进了这些细胞亚型的增殖和分化。缺乏或缺陷干细胞因子可导致造血祖细胞数量减少和严重贫血。CD117 也由黑色素细胞表达，并在这些细胞的信号传导和激活中起作用。

人 Human KIT 分子靶点信息

分子名：KIT, KIT proto-oncogene, receptor tyrosine kinase
别称：
- C-Kit
- c-Kit protooncogene
- CD117
- KIT proto-oncogene receptor tyrosine kinase
- mast/stem cell growth factor receptor
- mast/stem cell growth factor receptor Kit
- MASTC
- p145 c-kit
- PBT
- piebald trait
- piebald trait protein
- proto-oncogene c-Kit
- proto-oncogene tyrosine-protein kinase Kit
- SCFR
- soluble KIT variant 1
- tyrosine-protein kinase Kit
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
基因序列：NCBI_Gene: 3815
蛋白序列：UniProtKB: P10721

人 Human KIT靶点分子功能（预测）

Enables cytokine binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space; fibrillar center; and plasma membrane. Implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Biomarker of several diseases, including Hirschsprung's disease; invasive ductal carcinoma; oxyphilic adenoma; reproductive organ cancer (multiple); and urinary system cancer (multiple).