F2111705

Anti-Mouse CD117(c-Kit)，PE-Cy7 (Clone: ACK2) 流式抗体 (新品)

¥840.00 – ¥1,848.00

说明书

分子靶点：KIT, CD117, SCFR
种属：小鼠 (Mouse)
标记：PE-Cy7
亚型：Rat IgG2b, κ
克隆号：ACK2

在售SKU, 70-AM11710-20, 70-AM11710-50, 70-AM11710-100, AM11710, 70-F2111705-25, 70-F2111705-100

文章目录[隐藏]

分子信息
KIT 分子靶点信息概述
KIT 分子靶点综述
- 小鼠 Mouse Kit 分子靶点信息
- 小鼠 Mouse Kit 靶点分子功能（预测）

商品名	Anti-Mouse CD117(c-Kit)，PE-Cy7 (Clone: ACK2) 流式抗体
靶点	KIT, CD117, SCFR
标记	PE-Cy7
仪器	适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型	Rat IgG2b, κ
克隆号	ACK2
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

图 - 图. ICR 小鼠骨髓细胞染色 Anti-Mouse CD117 (c-Kit), PE-Cy7 (AM11710) 和Anti-Human/Mouse CD45R, FITC (AH045R01)的结果。已排除粘连细胞。

分子信息

概述小鼠 KIT, CD117, SCFR 靶点信息

KIT 分子靶点信息概述

分子名：KIT, KIT proto-oncogene, receptor tyrosine kinase
基因家族：Receptor tyrosine kinases; CD molecules; Immunoglobulin like domain containing
别名：CD117; SCFR; C-Kit
曾用名：PBT
全称：mast/stem cell growth factor receptor Kit; piebald trait; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

KIT 分子靶点综述

CD117 也称为 c-Kit、Steel 因子受体和干细胞因子受体，这种酪氨酸激酶蛋白主要表达于造血祖细胞、肥大细胞、急性髓系白血病细胞(AML)。CD117 激活促进了这些细胞亚型的增殖和分化。缺乏或缺陷干细胞因子可导致造血祖细胞数量减少和严重贫血。CD117 也由黑色素细胞表达，并在这些细胞的信号传导和激活中起作用。

小鼠 Mouse Kit 分子靶点信息

分子名：Kit, KIT proto-oncogene receptor tyrosine kinase
别称：
- belly-spot
- Bs
- c-KIT
- CD117
- dominant spotting
- Dominant white spotting
- Fdc
- gsf spotted coat 1
- gsf spotted coat 5
- Gsfsco1
- Gsfsco5
- Gsfsow3
- phenotype like Sl or W 3
- SCO1
- SCO5
- SOW3
- spotted sterile male
- Ssm
- Steel Factor Receptor
- Tr-kit
- W
基因序列：NCBI_Gene: 16590
蛋白序列：

小鼠 Mouse Kit 靶点分子功能（预测）

Enables SH2 domain binding activity; protease binding activity; and stem cell factor receptor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; erythropoietin-mediated signaling pathway; and hemopoiesis. Acts upstream of or within several processes, including ectopic germ cell programmed cell death; hemopoiesis; and positive regulation of macromolecule metabolic process. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).