Mouse LIF Standard (小鼠白血病抑制因子 标准品)

LIF 分子靶点信息概述

• 分子名：LIF, LIF interleukin 6 family cytokine
• 基因家族：Receptor ligands; Interleukin 6 type cytokine family
• 别名：CDF; DIA; HILDA
• 全称：differentiation inhibitory activity; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; human interleukin in DA cells; leukemia inhibitory factor; LIF, interleukin 6 family cytokine

LIF 分子靶点综述

白血病抑制因子(LIF)是一种白细胞介素6家族细胞因子，通过抑制分化影响细胞生长。当LIF水平下降时，细胞就会分化。活化的T细胞、单核细胞、星形胶质细胞、成骨细胞、角质形成细胞、肥大细胞和成纤维细胞都可表达LIF。LIF因其能诱导髓系白血病细胞的终端分化，阻止白血病细胞的持续增长而得名。LIF的其它特性包括促进生长、促进不同类型的靶细胞分化、影响骨代谢、恶病质、神经发育、胚胎发育和炎症。LIF参与孕期子宫内膜蜕膜化和胚胎植入子宫内膜的过程。女性体内的LIF和其它细胞因子水平下降时，就容易怀孕，但是不明原因复发性流产的风险会增加。研究表明重组人LIF可能有助于改善女性不明原因不孕不育的着床率。另外，LIF通常用来添加到干细胞培养基中来减少自发分化。

小鼠 Mouse Lif 分子靶点信息

• 分子名：Lif, leukemia inhibitory factor
• 别称：
  • 无
• 基因序列：NCBI_Gene: 16878
• 蛋白序列：
  • UniprotKB: P09056
  • UniprotKB: F8WH42
  • UniprotKB: Q3U1H5

小鼠 Mouse Lif 靶点分子功能（预测）

Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine).