EK2196S

Mouse IL-17F Standard (小鼠 IL-17F 标准品)

¥280.00

  • 分子靶点:IL17F, IL-17F, ML-1, ML1
  • 种属:小鼠 (Mouse)
  • 试剂盒:EK2196
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK2196S


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商品名

Mouse IL-17F Standard (小鼠 IL-17F 标准品)

组分

小鼠IL-17F标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述小鼠 IL17F, IL-17F, ML-1, ML1 靶点信息

IL17F 分子靶点信息概述

  • 分子名:IL17F, interleukin 17F
  • 基因家族:Interleukins
  • 别名:IL-17F; ML-1; ML1

IL17F 分子靶点综述

白细胞介素17F(IL-17F)和IL-17A是IL-17家族中紧密相关的两个成员,有大约50%氨基酸同源。IL-17F来源于不同细胞类型,如Th17细胞、肥大细胞和嗜碱性粒细胞,在组织中广泛表达,包括肺。IL-17F可诱导支气管上皮细胞、血管内皮细胞、成纤维细胞和嗜酸性粒细胞中的许多细胞因子、趋化因子和粘附分子。IL-17F利用IL-17RA和IL-17RC作为其受体,激活MAP激酶相关通路。小鼠气道IL-17F基因的过表达与气道中的中性粒细胞增多、多种细胞因子的诱导、气道高反应性和粘液高分泌增加有关。因此,IL-17F在过敏性气道炎症中可能起到重要作用,对哮喘有重要的治疗意义。

小鼠 Mouse Il17f 分子靶点信息

小鼠 Mouse Il17f 靶点分子功能(预测)

Enables cytokine receptor binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in defense response to bacterium and positive regulation of gene expression. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).

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引用文献


  1. IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells 

  2. Multifunctional Interleukin-24 Resolves Neuroretina Autoimmunity via Diverse Mechanisms 

  3. Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice 

  4. Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model 

  5. Isolation, purification and characterization of Pueraria lobata polysaccharide and its effects on intestinal function in cyclophosphamide-treated mice 

  6. Edible Bird’s Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance 

  7. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein 

  8. She-Chuang-Si-Wu-Tang Alleviates Inflammation and Itching Symptoms in a Psoriasis Mouse Model by Regulating the Th17/IL-17 Axis via the STAT3/MAPK Pathways 

  9. Unraveling CCL20's role by regulating Th17 cell chemotaxis in experimental autoimmune prostatitis 

  10. ILC2 regulates hyperoxia-induced lung injury via an enhanced Th17 cell response in the BPD mouse model