Mouse Adiponectin/Acrp30 Standard (小鼠Adiponectin/Acrp30 标准品)

ADIPOQ 分子靶点信息概述

• 分子名：ADIPOQ, adiponectin, C1Q and collagen domain containing
• 基因家族：C1q and TNF related
• 别名：ACRP30; apM1; GBP28; adiponectin
• 曾用名：ACDC
• 全称：adipose most abundant gene transcript 1; adiponectin precursor; adipocyte, C1Q and collagen domain containing

ADIPOQ 分子靶点综述

脂联素，又称脂肪细胞补体相关蛋白30(Acrp30)，参与调节葡萄糖水平和脂肪酸分解。它组装成不同的复合物包括三聚体、六聚体和高阶寡聚体结构，进而可能影响生物活性。脂联素是一种蛋白质激素，调节许多代谢过程，包括葡萄糖调节和脂肪酸氧化。脂肪组织(以及妊娠期的胎盘)专门分泌脂联素到血液中，因此相对于其它许多激素，血浆中的脂联素含量很丰富。脂联素可能具有抗动脉粥样硬化和消炎的作用，可负向调节粒单祖细胞的生长和TNF-α在巨噬细胞中的产生。监测一些病理状态下的血清脂联素水平，如2型糖尿病、肥胖、动脉粥样硬化和非酒精性脂肪肝疾病，可为我们了解脂联素提供更详细的见解。

小鼠 Mouse Adipoq 分子靶点信息

• 分子名：Adipoq, adiponectin, C1Q and collagen domain containing
• 别称：
  • Acdc
  • Acrp30
  • Ad
  • adipo
  • adipocyte complement related protein
  • adipocyte, C1Q and collagen domain containing
  • adiponectin
  • apM1
  • APN
  • GBP28
• 基因序列：NCBI_Gene: 11450
• 蛋白序列：
  • UniprotKB: Q60994
  • UniprotKB: E9PWU4
  • UniprotKB: Q8BRW2

小鼠 Mouse Adipoq 靶点分子功能（预测）

Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).