Human SP-D Standard (人表面活性蛋白D (SP-D) 标准品)

SFTPD 分子靶点信息概述

• 分子名：SFTPD, surfactant protein D
• 基因家族：Collectins; C-type lectin domain containing
• 别名：SP-D; COLEC7
• 曾用名：SFTP4
• 全称：surfactant, pulmonary-associated protein D

SFTPD 分子靶点综述

表面活性蛋白D (SP-D)分子量为43kDa，是具有先天免疫调节作用的胶原凝集素家族成员。它是由肺泡衬细胞和与管状结构相关的上皮细胞组成性分泌，且在心脏平滑肌和内皮细胞中诱导。人的SP-D存在于血清、血浆、支气管肺泡灌洗液和羊水中。SP-D在机体防御和先天性免疫方面发挥着重要作用。SP-D结合中性粒细胞防御素，调节抗病毒防御。目前的研究表明，SP-D 参与多种肺部疾病的发生、发展，可以作为这些疾病的生物标记。

人 Human SFTPD 分子靶点信息

• 分子名：SFTPD, surfactant protein D
• 别称：
  • COLEC7
  • collectin 7
  • collectin-7
  • lung surfactant protein D
  • PSP-D
  • pulmonary surfactant apoprotein
  • pulmonary surfactant-associated protein D
  • SFTP4
  • SP-D
  • surfactant-associated protein, pulmonary 4
  • surfactant, pulmonary-associated protein D
• 基因序列：NCBI_Gene: 6441
• 蛋白序列：UniProtKB: P35247

人 Human SFTPD靶点分子功能（预测）

Predicted to enable identical protein binding activity. Involved in several processes, including induction of bacterial agglutination; negative regulation by host of symbiont catalytic activity; and surfactant homeostasis. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space; multivesicular body; and rough endoplasmic reticulum. Implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Biomarker of several diseases, including cystic fibrosis; lung disease (multiple); respiratory syncytial virus infectious disease; sarcoidosis; and systemic lupus erythematosus.