SFTPD 靶点信息

SFTPD 分子靶点信息概述

  • 分子名：SFTPD, surfactant protein D
  • 基因家族：Collectins; C-type lectin domain containing
  • 别名：SP-D; COLEC7
  • 曾用名：SFTP4
  • 全称：surfactant, pulmonary-associated protein D

SFTPD 分子靶点综述

表面活性蛋白D (SP-D)分子量为43kDa，是具有先天免疫调节作用的胶原凝集素家族成员。它是由肺泡衬细胞和与管状结构相关的上皮细胞组成性分泌，且在心脏平滑肌和内皮细胞中诱导。人的SP-D存在于血清、血浆、支气管肺泡灌洗液和羊水中。SP-D在机体防御和先天性免疫方面发挥着重要作用。SP-D结合中性粒细胞防御素，调节抗病毒防御。目前的研究表明，SP-D 参与多种肺部疾病的发生、发展，可以作为这些疾病的生物标记。

SFTPD, surfactant protein D 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SFTPD 分子靶点信息

  • 分子名：SFTPD, surfactant protein D
  • 别称：
    • COLEC7
    • collectin 7
    • collectin-7
    • lung surfactant protein D
    • PSP-D
    • pulmonary surfactant apoprotein
    • pulmonary surfactant-associated protein D
    • SFTP4
    • SP-D
    • surfactant-associated protein, pulmonary 4
    • surfactant, pulmonary-associated protein D
  • 基因序列：NCBI_Gene: 6441
  • 蛋白序列：UniProtKB: P35247

人 Human SFTPD靶点分子功能（预测）

Predicted to enable identical protein binding activity. Involved in several processes, including induction of bacterial agglutination; negative regulation by host of symbiont catalytic activity; and surfactant homeostasis. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space; multivesicular body; and rough endoplasmic reticulum. Implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Biomarker of several diseases, including cystic fibrosis; lung disease (multiple); respiratory syncytial virus infectious disease; sarcoidosis; and systemic lupus erythematosus.

小鼠 Mouse Sftpd 分子靶点信息

  • 分子名：Sftpd, surfactant associated protein D
  • 别称：
    • AI573415
    • expressed sequence AI573415
    • Sfpd
    • Sftp4
    • SP-D
    • surfactant-associated protein 4
  • 基因序列：NCBI_Gene: 20390
  • 蛋白序列：

小鼠 Mouse Sftpd 靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in lung; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).

大鼠 Rat Sftpd 分子靶点信息

大鼠 Rat Sftpd 靶点分子功能（预测）

Enables identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of Coronavirus infectious disease; asthma; bacterial pneumonia; lung disease; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).

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