Human osteopontin/OPN ELISA Kit检测试剂盒(酶联免疫吸附法)
¥1,600.00 – ¥2,650.00
在售SKU:70-EK1135-48, 70-EK1135-96, EK1135
- 分子靶点:SPP1
- 种属:人
- 样本类型:血清、血浆、细胞培养上清及其他生物学样本
- 检测样本体积:血清、血浆样本5μL
- 灵敏度:4.42pg/mL
- 检测范围:125-8000pg/mL
- 回收率:75%-126%
ELISA试剂盒详细信息
商品名 | 人骨桥蛋白酶联免疫检测试剂盒 |
---|---|
种属 | 人 |
靶点 | SPP1 |
检测方法 | 双抗体夹心法 |
检测样本类型 | 血清、血浆、细胞培养上清及其他生物学样本 |
检测样本体积 | 血清、血浆样本5μL |
灵敏度 | 4.42pg/mL |
线性范围 | 125-8000pg/mL |
精密度 | 板内变异系数:4.1%-5.3%;板间变异系数:7.2%-9% |
回收率 | 75%-126% |
平均回收率 | 99% |
板式 | 96孔板,可拆 |
保存条件 | 2-8℃保存。已拆开:标准品-20℃保存,其它4℃。 |
运输条件 | 2-8℃冰袋运输 |
检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人OPN抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的OPN与固相抗体结合。洗涤去除未结合的物质后,加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中OPN的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。 |
分子信息
SPP1 分子靶点信息概述
- 分子名:SPP1, secreted phosphoprotein 1
- 基因家族:Receptor ligands; SIBLING family
- 别名:BSPI; ETA-1
- 曾用名:BNSP; OPN
- 全称:early T-lymphocyte activation 1; osteopontin; bone sialoprotein I
SPP1 分子靶点综述
骨桥蛋白(OPN),又名BSP-1、ETA-1、SPP-1或Ric,在人类中由SPP1基因编码,主要在骨骼中表达。OPN基因的调节机制还未完全阐明,不同细胞类型的调节机理是不同的。OPN在生物矿化、骨重塑、免疫功能、趋化、细胞活化和凋亡上有作用,同样与心肌细胞凋亡和心肌功能紊乱的增加有关。OPN与许多生理和病理过程包括伤口愈合、骨转换、肿瘤发生、炎症、缺血和免疫应答有关。调控血浆(或局部)的OPN水平对治疗自身免疫性疾病、癌症转移、骨和牙齿的矿化、骨质疏松症和一些应激形式有帮助。
人 Human SPP1 分子靶点信息
- 分子名:SPP1, secreted phosphoprotein 1
- 别称:
- BNSP
- bone sialoprotein 1
- bone sialoprotein I
- BSPI
- early T-lymphocyte activation 1
- ETA-1
- MGC110940
- nephropontin
- OPN
- osteopontin
- osteopontin-C
- osteopontin-D
- osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
- secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
- secreted phosphoprotein 1 variant 6
- secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
- SPP-1
- SPP1/CALPHA1 fusion
- urinary stone protein
- uropontin
- 基因序列:NCBI_Gene: 6696
- 蛋白序列:UniProtKB: P10451
人 Human SPP1靶点分子功能(预测)
Enables integrin binding activity. Involved in several processes, including androgen catabolic process; cellular response to testosterone stimulus; and positive regulation of estradiol secretion. Located in Golgi apparatus and extracellular space. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Biomarker of calcinosis; coronary artery disease; kidney failure; progressive osseous heteroplasia; and urinary bladder cancer.
引用文献统计
该产品被引用的文献总数为:7
- Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis
影响因子:7.109刊物:Cell Death Discovery发表日期:2022/3/4 - Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers
影响因子:6.832刊物:Bioengineered发表日期:2022/1/22 - Circulating osteopontin per tumor volume as a prognostic biomarker for resectable intrahepatic cholangiocarcinoma
影响因子:3.911刊物:Hepatobiliary Surgery and Nutrition发表日期:2019/12/1 - Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer
影响因子:11.059刊物:Journal of Hematology & Oncology发表日期:2020/12/7 - Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity
影响因子:6.2刊物:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY发表日期:2024-01-11 - MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma
影响因子:5.8刊物:iScience发表日期:2023-07-02 - Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis
刊物:Cell Death Discov. 2022 Mar 4;8(1):97.