Human MMP-9 Standard (人基质金属蛋白酶9标准品)

MMP9 分子靶点信息概述

• 分子名：MMP9, matrix metallopeptidase 9
• 基因家族：M10 matrix metallopeptidases
• 曾用名：CLG4B
• 全称：matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

MMP9 分子靶点综述

基质金属蛋白酶9(MMP-9)，又名92kDaIV型胶原酶、92kDa明胶酶或者明胶酶B，是一类属于锌-金属蛋白酶家族的酶。MMP-9参与正常生理过程(如胚胎发育、繁殖、血管形成、骨骼发育、伤口愈细胞迁移、学习和记忆)和病理过程(如关节炎、脑出血和肿瘤转移)的细胞外基质降解。MMP-9和弹性蛋白酶似乎是中性粒细胞迁移通过基底膜的调节因子。MMP-9在血管和新生血管形成中起重要作用。它在人类呼吸道上皮愈合过程中被显著上调，并被发现与许多病理过程相关，如癌症、免疫和心血管疾病。在类风湿性关节炎、局灶性脑缺血案例中可发现MMP-9的水平是升高的。它的水平随着特发性房颤的发展而增加。

人 Human MMP9 分子靶点信息

• 分子名：MMP9, matrix metallopeptidase 9
• 别称：
  • 92 kDa gelatinase
  • 92 kDa type IV collagenase
  • CLG4B
  • GELB
  • macrophage gelatinase
  • MANDP2
  • matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
  • matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
  • matrix metalloproteinase-9
  • MMP-9
  • type V collagenase
• 基因序列：NCBI_Gene: 4318
• 蛋白序列：UniProtKB: P14780

人 Human MMP9靶点分子功能（预测）

Enables identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of apoptotic signaling pathway; and positive regulation of keratinocyte migration. Located in extracellular space. Implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); brain disease (multiple); carcinoma (multiple); and lung disease (multiple).