Human Granzyme A Standard (人颗粒酶A (Granzyme A) 标准品)

GZMA 分子靶点信息概述

• 分子名：GZMA, granzyme A
• 基因家族：Granule associated serine proteases of immune defence
• 曾用名：HFSP; CTLA3
• 全称：CTL tryptase; Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease); granzyme 1; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

GZMA 分子靶点综述

颗粒酶 A (Granzyme A)是丝氨酸蛋白酶中颗粒酶家族的一员，专门存在于细胞毒性 T 淋巴细胞(CTL)和自然杀伤(NK) 细胞的颗粒中。Granzyme A 是 CTL 和 NK 细胞中最丰富的蛋白酶。它通过穿孔素进入到靶细胞，进而诱导 caspase 非 依赖性的细胞死亡。被赖氨酰肽链内切酶激活后，Granzyme A 就会裂解硫酯底物。人 Granzyme A 作为一个前体(262 个残基)被合成，这个前体带有一个信号肽(残基 1-26)、一个前肽(残基 27-28)和一条成熟链(残基 29-262)。纯化的重组 人 Granzyme A 由残基 26-262 组成。

人 Human GZMA 分子靶点信息

• 分子名：GZMA, granzyme A
• 别称：
  • CTL tryptase
  • CTLA3
  • cytotoxic T-lymphocyte proteinase 1
  • cytotoxic T-lymphocyte-associated serine esterase-3
  • fragmentin-1
  • granzyme 1
  • Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3, Hanukah factor serine protease)
  • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
  • granzyme-1
  • h factor
  • hanukah factor serine protease
  • Hanukah factor serine protease)
  • hanukkah factor
  • HF
  • HFSP
• 基因序列：NCBI_Gene: 3001
• 蛋白序列：UniProtKB: P12544

人 Human GZMA靶点分子功能（预测）

Enables protein homodimerization activity and serine-type endopeptidase activity. Involved in several processes, including cytotoxic T cell pyroptotic process; granzyme-mediated programmed cell death signaling pathway; and negative regulation of endodeoxyribonuclease activity. Predicted to be located in immunological synapse and nucleus. Biomarker of chronic obstructive pulmonary disease.