EK163S

Human GM-CSF Standard (人粒-巨噬细胞集落刺激因子 标准品)

¥180.00

  • 分子靶点:CSF2, GM-CSF
  • 种属:人 (Human)
  • 试剂盒:EK163
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK163S


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商品名

Human GM-CSF Standard (人粒-巨噬细胞集落刺激因子 标准品)

组分

人粒-巨噬细胞集落刺激因子标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 CSF2, GM-CSF 靶点信息

CSF2 分子靶点信息概述

  • 分子名:CSF2, colony stimulating factor 2
  • 别名:GM-CSF; GMCSF
  • 全称:sargramostim; molgramostim; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage)

CSF2 分子靶点综述

粒细胞-巨噬细胞集落刺激因子(GM-CSF)是一种调节白细胞生长的细胞因子。GM-CSF刺激干细胞产生粒细胞(中性粒细胞、嗜酸性粒细胞和嗜碱性粒细胞)及单核细胞。此外,它对造血和非造血谱系细胞也具有活性。GM-CSF用作药物来刺激白细胞的产生,从而预防化疗后引起的中性粒细胞减少症。近来,人们正在临床试验评估GM-CSF作为一种潜在的疫苗佐剂对HIV感染患者的疗效。相关研究报道一些癌症(包括肺癌和急性髓细胞白血病)患者的血清中具有较高水平的GM-CSF,同样在支气管哮喘患者外周血和鳞屑提取物中也具有较高水平的GM-CSF。

人 Human CSF2 分子靶点信息

  • 分子名:CSF2, colony stimulating factor 2
  • 别称:
    • colony stimulating factor 2 (granulocyte-macrophage)
    • colony-stimulating factor
    • CSF
    • GMCSF
    • granulocyte macrophage-colony stimulating factor
    • granulocyte-macrophage colony stimulating factor
    • granulocyte-macrophage colony-stimulating factor
    • MGC131935
    • MGC138897
    • molgramostim
    • molgramostin
    • sargramostim
  • 基因序列:NCBI_Gene: 1437
  • 蛋白序列:UniProtKB: P04141

人 Human CSF2靶点分子功能(预测)

Enables cytokine activity. Involved in several processes, including cellular response to granulocyte macrophage colony-stimulating factor stimulus; myeloid leukocyte differentiation; and positive regulation of macromolecule metabolic process. Located in extracellular space and intracellular membrane-bounded organelle. Implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Biomarker of COVID-19; asthma; chronic obstructive pulmonary disease; and temporal arteritis.

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  1. Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma 

  2. Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy 

  3. Decidua-derived granulocyte macrophage colony-stimulating factor induces polymorphonuclear myeloid-derived suppressor cells from circulating CD15+ neutrophils 

  4. Nanobody-based CAR T cells targeting intracellular tumor antigens 

  5. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis 

  6. Tumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis 

  7. Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors 

  8. An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation 

  9. GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer. 

  10. Impaired myeloid-derived suppressor cells are associated with recurrent implantation failure: A case-control study 

  11. IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation 

  12. CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway 

  13. 细胞培养上清

    Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy 

  14. A Vascular Disrupting Agent Overcomes Tumor Multidrug Resistance by Skewing Macrophage Polarity toward the M1 Phenotype