Human G-CSF High Sensitivity Standard (人粒细胞集落刺激因子高敏标准品)

CSF3 分子靶点信息概述

• 分子名：CSF3, colony stimulating factor 3
• 基因家族：Receptor ligands
• 别名：MGC45931
• 曾用名：GCSF; G-CSF; C17orf33
• 全称：granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte)

CSF3 分子靶点综述

粒细胞集落刺激因子(G-CSF)是一种糖蛋白，可刺激骨髓产生粒细胞和干细胞，并把它们释放到血液中。从功能上来说，它是一种细胞因子和激素，是一种集落刺激因子，由内皮细胞、巨噬细胞和许多其它免疫细胞产生。G-CSF刺激中性粒细胞前体和成熟中性粒细胞的生存、增殖、分化及功能发挥。在肿瘤学和血液学上，重组G-CSF用于加速癌症患者化疗后引起的嗜中性白血球减少症的恢复。在白细胞去除前，G-CSF也可用来增加献血者血液中的造血干细胞数量，用于造血干细胞移植。

人 Human CSF3 分子靶点信息

• 分子名：CSF3, colony stimulating factor 3
• 别称：
  • C17orf33
  • chromosome 17 open reading frame 33
  • colony stimulating factor 3 (granulocyte)
  • CSF3OS
  • filgrastim
  • G-CSF
  • GCSF
  • granulocyte colony-stimulating factor
  • granulocyte-colony stimulating factor
  • lenograstim
  • MGC45931
  • pluripoietin
• 基因序列：NCBI_Gene: 1440
• 蛋白序列：UniProtKB: P09919

人 Human CSF3靶点分子功能（预测）

Enables cytokine activity and enzyme binding activity. Involved in several processes, including positive regulation of cytoskeleton organization; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Predicted to be located in endocytic vesicle lumen; extracellular region; and lysosomal lumen. Predicted to be active in extracellular space. Implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Biomarker of COVID-19; bacterial pneumonia; and myeloid leukemia.