EK1242

Human FGFR2 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

说明书

在售SKU:70-EK1242-48, 70-EK1242-96, EK1242, 人成纤维细胞生长因子2, 人, 成纤维细胞, 成纤维细胞生长因子, 生长因子2

分子靶点：FGFR2
种属：人
样本类型：血清、血浆、细胞培养上清及其他生物学样本
检测样本体积：50μL血清
灵敏度：4.14pg/mL
检测范围：31.25-2000pg/mL
回收率：71%-124%

ELISA试剂盒详细信息

商品名	人成纤维细胞生长因子受体2酶联免疫检测试剂盒
种属	人
靶点	FGFR2
检测方法	双抗体夹心法
检测样本类型	血清、血浆、细胞培养上清及其他生物学样本
检测样本体积	50μL血清
灵敏度	4.14pg/mL
线性范围	31.25-2000pg/mL
精密度	板内变异系数：3.0%-7.6%;板间变异系数：5.1%-6.8%
回收率	71%-124%
平均回收率	107%
板式	96孔板，可拆
保存条件	2-8℃保存。已拆开：标准品-20℃保存，其它4℃。
运输条件	2-8℃冰袋运输
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人FGFR2抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和辣根过氧化物酶标记的检测抗体，经过孵育，样本中存在的FGFR2与固相抗体和检测抗体结合。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中FGFR2的浓度成正比。加入终止液终止反应，在450nm波长(参考波长570 - 630nm)测定吸光度值。

文章目录[隐藏]

FGFR2 分子靶点信息概述
FGFR2 分子靶点综述
FGFR2, fibroblast growth factor receptor 2 分子靶点种属信息

FGFR2 分子靶点信息概述

分子名：FGFR2, fibroblast growth factor receptor 2
基因家族：I-set domain containing; Receptor tyrosine kinases; CD molecules
别名：CEK3; TK14; TK25; ECT1; K-SAM; CD332
曾用名：KGFR; BEK; CFD1; JWS
全称：bacteria-expressed kinase; keratinocyte growth factor receptor; craniofacial dysostosis 1; Jackson-Weiss syndrome;
Crouzon syndrome; Pfeiffer syndrome

FGFR2 分子靶点综述

成纤维细胞生长因子受体 2 (Fibroblast growth factor receptor 2, FGFR2)是一种酪氨酸激酶受体。该受体目前发现有 FGFR1、FGFR2、FGFR3 和FGFR4，是一种跨膜蛋白质, 分别为细胞外、跨膜部分、胞内近膜区和胞内结构区( 酪氨酸激酶区) , 为配体的特异性结合提供了受体的分子基础。成纤维细胞生长因子受体(Fibroblast growth factor receptors, FGFR）家族，能促进细胞生长、提高细胞侵袭力和活力以及促进血管新生。其中人成纤维细胞生长因子2 (FGFR2)的表达异常与基因多态性与多种肿瘤相关，如乳腺癌、胆管癌、肺癌等，并且与肿瘤细胞增生、侵袭有关。

FGFR2, fibroblast growth factor receptor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGFR2 分子靶点信息

分子名：FGFR2, fibroblast growth factor receptor 2
别称：
- bacteria-expressed kinase
- BBDS
- BEK
- BEK fibroblast growth factor receptor
- BFR-1
- CD332
- CEK3
- CFD1
- ECT1
- FGF receptor
- FGFR-2
- FGFR2-AHCYL1 fusion kinase protein
- fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
- fibroblast growth factor receptor 2 isoform IgIIIb isoform
- fibroblast growth factor receptor 2 isoform IgIIIc isoform
- fibroblast growth factor receptor 2 Ksam IV secreted isoform
- FLJ98662
- hydroxyaryl-protein kinase
- JWS
- K-SAM
- keratinocyte growth factor receptor
- KGFR
- protein tyrosine kinase, receptor like 14
- soluble FGFR4 variant 4
- TK14
- TK25
基因序列：NCBI_Gene: 2263
蛋白序列：UniProtKB: P21802

人 Human EGFR靶点分子功能（预测）

Enables fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; negative regulation of keratinocyte proliferation; and protein phosphorylation. Located in cell cortex; cell surface; and nucleus. Is integral component of plasma membrane. Colocalizes with collagen-containing extracellular matrix. Implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Biomarker of endometriosis; prostate cancer; squamous cell carcinoma; stomach cancer; and transitional cell carcinoma.

小鼠 Mouse Fgfr2 分子靶点信息

分子名：Fgfr2, fibroblast growth factor receptor 2
别称：
- AU043015
- AW556123
- bacterially expressed kinase
- Bek
- expressed sequence AU043015
- expressed sequence AW556123
- Fgfr-2
- Fgfr-7
- Fgfr2b
- Fgfr7
- fibroblast growth factor receptor 7
- KGFRTr
- seminal vesicle shape
- svs
基因序列：NCBI_Gene: 14183
蛋白序列：

小鼠 Mouse Fgfr2 靶点分子功能（预测）

Enables fibroblast growth factor binding activity. Involved in fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including cardiac chamber morphogenesis; lung development; and morphogenesis of an epithelium. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).

大鼠 Rat Fgfr2 分子靶点信息

分子名：Fgfr2, fibroblast growth factor receptor 2
基因序列：NCBI_Gene: 25022
蛋白序列：

大鼠 Rat Fgfr2 靶点分子功能（预测）

Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of smooth muscle cell proliferation. Located in cell surface; cytoplasm; and nucleus. Used to study prostate cancer and retinitis pigmentosa. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).