Human CXCL10/IP-10 Standard (人趋化因子CXC配体10/γ-干扰素诱导蛋白10 标准品)

CXCL10 分子靶点信息概述

• 分子名：CXCL10, C-X-C motif chemokine ligand 10
• 基因家族：Chemokine ligands
• 别名：IFI10; IP-10; crg-2; mob-1; C7; gIP-10
• 曾用名：INP10; SCYB10
• 全称：small inducible cytokine subfamily B (Cys-X-Cys), member 10; chemokine (C-X-C motif) ligand 10

CXCL10 分子靶点综述

趋化因子配体10(CXCL10)又称为γ-干扰素诱导蛋白10(IP-10)或微小诱导细胞因子B10，是属于CXC趋化因子家族的小分子量细胞因子。多种类型的细胞对IFN-γ产生应答后可分泌IP-10，包括单核细胞、内皮细胞和成纤维细胞等。IP-10具有多种功能，如对单核/巨噬细胞、T细胞、NK细胞和树突细胞的趋化作用，促进T细胞黏附于内皮细胞，抗肿瘤活性和抑制骨髓集落形成和血管生成。

人 Human CXCL10 分子靶点信息

• 分子名：CXCL10, C-X-C motif chemokine ligand 10
• 别称：
  • 10 kDa interferon gamma-induced protein
  • C-X-C motif chemokine 10
  • C7
  • chemokine (C-X-C motif) ligand 10
  • crg-2
  • gamma IP10
  • gamma-IP10
  • gIP-10
  • IFI10
  • INP10
  • interferon-inducible cytokine IP-10
  • IP-10
  • mob-1
  • protein 10 from interferon (gamma)-induced cell line
  • SCYB10
  • small inducible cytokine subfamily B (Cys-X-Cys), member 10
  • small-inducible cytokine B10
• 基因序列：NCBI_Gene: 3627
• 蛋白序列：UniProtKB: P02778

人 Human CXCL10靶点分子功能（预测）

Enables chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of leukocyte chemotaxis; and response to virus. Acts upstream of or within cellular response to lipopolysaccharide and positive regulation of T cell migration. Located in extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).