CXCL10 靶点信息

CXCL10 分子靶点信息概述

  • 分子名：CXCL10, C-X-C motif chemokine ligand 10
  • 基因家族：Chemokine ligands
  • 别名：IFI10; IP-10; crg-2; mob-1; C7; gIP-10
  • 曾用名：INP10; SCYB10
  • 全称：small inducible cytokine subfamily B (Cys-X-Cys), member 10; chemokine (C-X-C motif) ligand 10

CXCL10 分子靶点综述

趋化因子配体10(CXCL10)又称为γ-干扰素诱导蛋白10(IP-10)或微小诱导细胞因子B10，是属于CXC趋化因子家族的小分子量细胞因子。多种类型的细胞对IFN-γ产生应答后可分泌IP-10，包括单核细胞、内皮细胞和成纤维细胞等。IP-10具有多种功能，如对单核/巨噬细胞、T细胞、NK细胞和树突细胞的趋化作用，促进T细胞黏附于内皮细胞，抗肿瘤活性和抑制骨髓集落形成和血管生成。

CXCL10, C-X-C motif chemokine ligand 10 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL10 分子靶点信息

  • 分子名：CXCL10, C-X-C motif chemokine ligand 10
  • 别称：
    • 10 kDa interferon gamma-induced protein
    • C-X-C motif chemokine 10
    • C7
    • chemokine (C-X-C motif) ligand 10
    • crg-2
    • gamma IP10
    • gamma-IP10
    • gIP-10
    • IFI10
    • INP10
    • interferon-inducible cytokine IP-10
    • IP-10
    • mob-1
    • protein 10 from interferon (gamma)-induced cell line
    • SCYB10
    • small inducible cytokine subfamily B (Cys-X-Cys), member 10
    • small-inducible cytokine B10
  • 基因序列：NCBI_Gene: 3627
  • 蛋白序列：UniProtKB: P02778

人 Human CXCL10靶点分子功能（预测）

Enables chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of leukocyte chemotaxis; and response to virus. Acts upstream of or within cellular response to lipopolysaccharide and positive regulation of T cell migration. Located in extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).

小鼠 Mouse Cxcl10 分子靶点信息

小鼠 Mouse Cxcl10 靶点分子功能（预测）

Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10).

大鼠 Rat Cxcl10 分子靶点信息

  • 分子名：Cxcl10, C-X-C motif chemokine ligand 10
  • 别称：
    • 10 kDa interferon gamma-induced protein
    • C-X-C motif chemokine 10
    • chemokine (C-X-C motif) ligand 10
    • gamma-IP10
    • interferon-inducible cytokine IP-10
    • interferon-inducible protein 10
    • IP-10
    • protein Mob-1
    • Scyb10
    • small inducible cytokine B subfamily (Cys-X-Cys) member 10
    • small inducible cytokine B subfamily (Cys-X-Cys), member 10
    • small-inducible cytokine B10
  • 基因序列：NCBI_Gene: 245920
  • 蛋白序列：UniProtKB: P48973

大鼠 Rat Cxcl10 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10).

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