Human CEACAM1/CD66a Standard (人癌胚抗原相关细胞粘附分子1 标准品)

CEACAM1 分子靶点信息概述

• 分子名：CEACAM1, CEA cell adhesion molecule 1
• 基因家族：CD molecules; V-set domain containing; CEA cell adhesion molecule family
• 别名：BGP1; CD66a
• 曾用名：BGP
• 全称：carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); carcinoembryonic antigen related cell adhesion molecule 1

CEACAM1 分子靶点综述

癌胚抗原相关细胞粘附分子1 (CEACAM1)，又名CD66a，是免疫球蛋白超家族中的癌胚抗原(CEA)基因家族中的成员。高度糖基化的CEACAM1包含一个N端V型Ig样结构域、三个C2型Ig样结构域、一个ITIM基序和一个胞质区钙调素结合位点。CEACAM1是一个在多种血细胞、上皮细胞和血管细胞中表达的表面糖蛋白。它是存在于粒细胞、上皮细胞和内皮细胞中的一个粘附分子，可通过嗜同种和异嗜性的方式来介导细胞粘附。研究显示，CEACAM1在多种细胞过程包括组织分化、血管生成、凋亡、转移、固有免疫和适应性免疫应答调控中起作用。

人 Human CEACAM1 分子靶点信息

• 分子名：CEACAM1, CEA cell adhesion molecule 1
• 别称：
  • antigen CD66
  • BGP
  • BGP-1
  • BGP1
  • BGPI
  • biliary glycoprotein 1
  • biliary glycoprotein adhesion molecule
  • carcinoembryonic antigen related cell adhesion molecule 1
  • carcinoembryonic antigen-related cell adhesion molecule 1
  • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
  • CD66a antigen
• 基因序列：NCBI_Gene: 634
• 蛋白序列：UniProtKB: P13688

人 Human CEACAM1靶点分子功能（预测）

Enables cytoskeletal protein binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of leukocyte mediated cytotoxicity; and wound healing, spreading of cells. Located in apical plasma membrane; cell surface; and cell-cell junction. Is integral component of membrane. Colocalizes with T cell receptor complex.