CEACAM1 靶点信息

CEACAM1 分子靶点信息概述

  • 分子名：CEACAM1, CEA cell adhesion molecule 1
  • 基因家族：CD molecules; V-set domain containing; CEA cell adhesion molecule family
  • 别名：BGP1; CD66a
  • 曾用名：BGP
  • 全称：carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); carcinoembryonic antigen related cell adhesion molecule 1

CEACAM1 分子靶点综述

癌胚抗原相关细胞粘附分子1 (CEACAM1)，又名CD66a，是免疫球蛋白超家族中的癌胚抗原(CEA)基因家族中的成员。高度糖基化的CEACAM1包含一个N端V型Ig样结构域、三个C2型Ig样结构域、一个ITIM基序和一个胞质区钙调素结合位点。CEACAM1是一个在多种血细胞、上皮细胞和血管细胞中表达的表面糖蛋白。它是存在于粒细胞、上皮细胞和内皮细胞中的一个粘附分子，可通过嗜同种和异嗜性的方式来介导细胞粘附。研究显示，CEACAM1在多种细胞过程包括组织分化、血管生成、凋亡、转移、固有免疫和适应性免疫应答调控中起作用。

CEACAM1, CEA cell adhesion molecule 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CEACAM1 分子靶点信息

  • 分子名：CEACAM1, CEA cell adhesion molecule 1
  • 别称：
    • antigen CD66
    • BGP
    • BGP-1
    • BGP1
    • BGPI
    • biliary glycoprotein 1
    • biliary glycoprotein adhesion molecule
    • carcinoembryonic antigen related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    • CD66a antigen
  • 基因序列：NCBI_Gene: 634
  • 蛋白序列：UniProtKB: P13688

人 Human CEACAM1靶点分子功能（预测）

Enables cytoskeletal protein binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of leukocyte mediated cytotoxicity; and wound healing, spreading of cells. Located in apical plasma membrane; cell surface; and cell-cell junction. Is integral component of membrane. Colocalizes with T cell receptor complex.

小鼠 Mouse Ceacam1 分子靶点信息

小鼠 Mouse Ceacam1 靶点分子功能（预测）

Enables several functions, including signaling receptor binding activity; virion binding activity; and virus receptor activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including modulation by host of viral process; regulation of T cell activation; and regulation of intracellular signal transduction. Located in cell projection membrane; external side of plasma membrane; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1).

大鼠 Rat Ceacam1 分子靶点信息

  • 分子名：Ceacam1, CEA cell adhesion molecule 1
  • 别称：
    • adhesion molecule, CEA-like
    • adhesion molecule, CEA-like (mapped)
    • ATP-dependent taurocolate-carrier protein
    • Bgp
    • BGPR
    • C-CAM 105
    • carcinoembryonic antigen related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule
    • carcinoembryonic antigen-related cell adhesion molecule 1
    • carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    • Ccam1
    • Ccam1_mapped
    • CD66a
    • CEA-related cell adhesion molecule 1
    • CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin)
    • cell-CAM 105
    • ecto-ATPase
    • GP110
    • osteocalcin
    • pp120
    • pp120/ecto-ATPase
  • 基因序列：NCBI_Gene: 81613
  • 蛋白序列：

大鼠 Rat Ceacam1 靶点分子功能（预测）

Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; and lateral plasma membrane. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1).

CEACAM1 分子产品列表

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