EK1211S

Human CCL20/MIP-3α Standard (人趋化因子配体20 (CCL20) 标准品)

¥280.00

  • 分子靶点:CCL20, MIP-3, LARC, ST38
  • 种属:人 (Human)
  • 试剂盒:EK1211
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1211S


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商品名

Human CCL20/MIP-3α Standard (人趋化因子配体20 (CCL20) 标准品)

组分

人CCL20/MIP-3α 标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 CCL20, MIP-3, LARC, ST38 靶点信息

CCL20 分子靶点信息概述

  • 分子名:CCL20, C-C motif chemokine ligand 20
  • 基因家族:Chemokine ligands
  • 别名:LARC; MIP-3a; exodus-1; ST38; CKb4
  • 曾用名:SCYA20
  • 全称:small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (C-C motif) ligand 20

CCL20 分子靶点综述

趋化因子配体20(CCL20),又名巨噬细胞炎性蛋白3α(MIP-3α),是CC趋化因子家族的小分子量细胞因子。CCL20对淋巴细胞具有强烈的趋化作用,而对中性粒细胞的趋化作用较弱。单核细胞、巨噬细胞、小胶质细胞、星形胶质细胞、肥大细胞、角质细胞、肠上皮细胞、成骨细胞、成纤维细胞、内皮细胞和支气管上皮细胞都可表达CCL20。CCL20趋化淋巴细胞和树突状细胞到粘膜淋巴组织周围的上皮细胞,从而参与粘膜淋巴组织的形成和功能的发挥。CCL20结合并激活趋化因子受体CCR6来作用于靶细胞。CCL20在中枢神经系统的自身免疫性疾病发病过程中可能起到重要作用。

人 Human CCL20 分子靶点信息

  • 分子名:CCL20, C-C motif chemokine ligand 20
  • 别称:
    • beta chemokine exodus-1
    • beta-chemokine exodus-1
    • C-C motif chemokine 20
    • CC chemokine LARC
    • chemokine (C-C motif) ligand 20
    • CKb4
    • Exodus
    • exodus-1
    • LARC
    • liver and activation-regulated chemokine
    • macrophage inflammatory protein 3 alpha
    • MIP-3-alpha
    • MIP-3a
    • MIP3A
    • SCYA20
    • small inducible cytokine subfamily A (Cys-Cys), member 20
    • small-inducible cytokine A20
    • ST38
  • 基因序列:NCBI_Gene: 6364
  • 蛋白序列:UniProtKB: P78556

人 Human CCL20靶点分子功能(预测)

Enables CCR6 chemokine receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; calcium-mediated signaling using intracellular calcium source; and cell chemotaxis. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including IgA glomerulonephritis; Lyme disease; anogenital venereal wart; dermatitis (multiple); and skin papilloma.

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引用文献


  1. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6 

  2. LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure 

  3. KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3 

  4. Identification of CCL20 as a prognostic predictor for severe fever with thrombocytopenia syndrome based on plasma proteomics 

  5. LPCAT1 facilitates keratinocyte hyperproliferation and skin inflammation in psoriasis via regulating GLUT3 

  6. Association Between Serum Chemokine Ligand 20 Levels and Disease Activity and Th1/Th2/Th17-Related Cytokine Levels in Rheumatoid Arthritis