Human Apolipoprotein H/Apo H Standard (人载脂蛋白H (Apo H) 标准品)

APOH 分子靶点信息概述

• 分子名：APOH, apolipoprotein H
• 基因家族：Apolipoproteins; Sushi domain containing
• 别名：BG
• 曾用名：B2G1
• 全称：beta-2-glycoprotein I; apolipoprotein H (beta-2-glycoprotein I)

APOH 分子靶点综述

载脂蛋白H(ApoH)，又称为β2糖蛋白I，是一个多功能载脂蛋白，在人类中由APOH基因编码。它是一种由肝细胞合成的糖蛋白，功能之一是结合磷脂。ApoH可结合到多种带负电荷的物质上，如肝素、磷脂和硫酸葡聚糖。ApoH参与凝集过程很复杂，可改变ADP介导的血小板凝集。它与受损细胞表面的磷脂结合，进而阻止先天性凝血级联的激活。通常，血清中的ApoH呈现出抗凝血活性(通过抑制凝血因子)。它的血浆浓度与代谢综合征的改变和2型糖尿病的血管病变密切相关，被作为评估心血管风险的临床指标。

人 Human APOH 分子靶点信息

• 分子名：APOH, apolipoprotein H
• 别称：
  • activated protein C-binding protein
  • anticardiolipin cofactor
  • APC inhibitor
  • apo-H
  • apolipoprotein H (beta-2-glycoprotein I)
  • B2G1
  • B2GP1
  • B2GPI
  • beta-2-glycoprotein 1
  • beta(2)GPI
  • BG
• 基因序列：NCBI_Gene: 350
• 蛋白序列：UniProtKB: P02749

人 Human APOH靶点分子功能（预测）

Enables identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Involved in several processes, including blood coagulation, intrinsic pathway; negative regulation of apoptotic process; and regulation of blood coagulation. Located in cell surface and extracellular space. Part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with collagen-containing extracellular matrix. Implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Biomarker of arteriosclerosis; diabetes mellitus; diabetic retinopathy; macular retinal edema; and type 2 diabetes mellitus.