Anti-Mouse CD86 (B7-2), FITC (Clone:GL-1) 流式抗体 (新品)

CD86 分子靶点信息概述

• 分子名：CD86, CD86 molecule
• 基因家族：CD molecules; V-set domain containing; B7 family
• 别名：B7.2; B7-2
• 曾用名：CD28LG2
• 全称：B-lymphocyte antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

CD86 分子靶点综述

CD86也称为B7.2，分子量80 kD，表达于树突状细胞、单核细胞、记忆T淋巴细胞、生发中心B淋巴细胞、活化B淋巴细胞以及活化T淋巴细胞。属于免疫球蛋白超家族，其配体是CD28和CD152 (CTLA4)。CD86与诱导剂CD28和抑制剂CTLA4相互作用，是诱导T淋巴细胞增殖及产生IL-2的主要协同因子。

小鼠 Mouse Cd86 分子靶点信息

• 分子名：Cd86, CD86 antigen
• 别称：
  • B7-2
  • B7.2
  • B70
  • CD28 antigen ligand
  • Cd28l2
  • Ly-58
  • Ly58
  • lymphocyte antigen 58
  • MB7-2
• 基因序列：NCBI_Gene: 12524
• 蛋白序列：
  • UniprotKB: P42082
  • UniprotKB: A0A0X9RAD7
  • UniprotKB: Q3T9F8
  • UniprotKB: Q3TDR5
  • UniprotKB: Q549Q9
  • UniprotKB: Q61238
  • UniprotKB: Q91YV7

小鼠 Mouse Cd86 靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).