文章目录[隐藏]
CD86 分子靶点信息概述
- 分子名：CD86, CD86 molecule
- 基因家族：CD molecules; V-set domain containing; B7 family
- 别名：B7.2; B7-2
- 曾用名：CD28LG2
- 全称：B-lymphocyte antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
CD86 分子靶点综述
CD86也称为B7.2，分子量80 kD，表达于树突状细胞、单核细胞、记忆T淋巴细胞、生发中心B淋巴细胞、活化B淋巴细胞以及活化T淋巴细胞。属于免疫球蛋白超家族，其配体是CD28和CD152 (CTLA4)。CD86与诱导剂CD28和抑制剂CTLA4相互作用，是诱导T淋巴细胞增殖及产生IL-2的主要协同因子。
CD86, CD86 molecule 分子靶点种属信息
人 Human CD86 分子靶点信息
- 分子名：CD86, CD86 molecule
- 别称：
- activation B7-2 antigen
- B-lymphocyte activation antigen B7-2
- B-lymphocyte antigen B7-2
- B7-2
- B7-2 antigen
- B7.2
- B70
- BU63
- CD28 antigen ligand 2
- CD28LG2
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
- CTLA-4 counter-receptor B7.2
- FUN-1
- LAB72
- MGC34413
- T-lymphocyte activation antigen CD86
- 基因序列：NCBI_Gene: 942
- 蛋白序列：UniProtKB: P42081
人 Human CD86靶点分子功能（预测）
Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including CD40 signaling pathway; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within defense response to virus and toll-like receptor signaling pathway. Located in centriolar satellite; extracellular exosome; and plasma membrane. Implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
小鼠 Mouse Cd86 分子靶点信息
- 分子名：Cd86, CD86 antigen
- 别称：
- B7-2
- B7.2
- B70
- CD28 antigen ligand
- Cd28l2
- Ly-58
- Ly58
- lymphocyte antigen 58
- MB7-2
- 基因序列：NCBI_Gene: 12524
- 蛋白序列：
小鼠 Mouse Cd86 靶点分子功能（预测）
Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
大鼠 Rat Cd86 分子靶点信息
- 分子名：Cd86, CD86 molecule
- 别称：
- B7-2
- cd86 antigen
- membrane glycoprotein
- T-lymphocyte activation antigen CD86
- 基因序列：NCBI_Gene: 56822
- 蛋白序列：
大鼠 Rat Cd86 靶点分子功能（预测）
Enables signaling receptor binding activity. Involved in several processes, including defense response to other organism; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
