Human IL-21 High Sensitivity Standard (人白介素21 高敏标准品)

IL21 分子靶点信息概述

• 分子名：IL21, interleukin 21
• 基因家族：Interleukins
• 别名：Za11; IL-21

IL21 分子靶点综述

白细胞介素21(IL-21)对免疫细胞具有强烈的调节作用，包括可破坏病毒感染或肿瘤细胞的自然杀伤细胞(NK)和细胞毒性T细胞。该细胞因子可诱导靶细胞分裂/增殖。IL-21表达于人活化的CD4+T细胞，但在其他大多数组织中并没有表达。此外，IL-21在辅助性T细胞亚群Th2和Th17细胞以及滤泡性T细胞中表达上调。而且IL-21还表达于调控这些细胞功能的NKT细胞中。IL-21在免疫炎性疾病中具有病理作用。研究表明存在一个正向自分泌环，可放大并稳定IL-21驱使的、T细胞介导的应答。而且，它还具有抗肿瘤活性，对自身免疫进程具有作用。在临床上，IL-21还可作为潜在的抗肿瘤药物。

人 Human IL21 分子靶点信息

• 分子名：IL21, interleukin 21
• 别称：
  • CVID11
  • IL-21
  • interleukin-21
  • interleukin-21 isoform
  • Za11
• 基因序列：NCBI_Gene: 59067
• 蛋白序列：UniProtKB: Q9HBE4

人 Human IL21靶点分子功能（预测）

Enables interleukin-2 receptor binding activity. Involved in several processes, including positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; and tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of B cell proliferation; positive regulation of T cell proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular region. Implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Biomarker of several diseases, including anogenital venereal wart; autoimmune disease (multiple); dengue hemorrhagic fever; human immunodeficiency virus infectious disease; and tropical spastic paraparesis.