文章目录[隐藏]
TNF 分子靶点信息概述
- 分子名:TNF, tumor necrosis factor
- 基因家族:Tumor necrosis factor superfamily
- 别名:TNFSF2; DIF; TNF-alpha
- 曾用名:TNFA
- 全称:TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)
TNF 分子靶点综述
TNF-α 为单核细胞、巨噬细胞、中性粒细胞、NK 细胞和 CD4+T 细胞产生的 17 kDa 细胞因子。它在免疫应答中具有多种调节功能,还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后,在全身循环,激活中性粒细胞,改变血管内皮细胞的特性,调控其它组织的代谢活性,以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。
TNF, tumor necrosis factor 分子靶点种属信息
人 Human TNF 分子靶点信息
- 分子名:TNF, tumor necrosis factor
- 别称:
- APC1 protein
- cachectin
- DIF
- TNF superfamily, member 2
- TNF-a
- TNF-alpha
- TNF, macrophage-derived
- TNF, monocyte-derived
- TNFA
- TNFSF2
- TNLG1F
- tumor necrosis factor alpha
- tumor necrosis factor ligand 1F
- tumor necrosis factor ligand superfamily member 2
- tumor necrosis factor-alpha
- 基因序列:NCBI_Gene: 7124
- 蛋白序列:UniProtKB: P01375
人 Human TNF靶点分子功能(预测)
Enables several functions, including identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Acts upstream of or within several processes, including regulation of cellular protein metabolic process; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular space; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).
小鼠 Mouse Tnf 分子靶点信息
- 分子名:Tnf, tumor necrosis factor
- 别称:
- DIF
- TNF alpha
- TNF-alpha
- Tnfa
- TNFalpha
- Tnfsf1a
- tumor necrosis factor-alpha
- tumor necrosis factor, alpha
- 基因序列:NCBI_Gene: 21926
- 蛋白序列:
小鼠 Mouse Tnf 靶点分子功能(预测)
Enables cytokine activity; protease binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of intracellular signal transduction; and regulation of gene expression. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is expressed in several structures, including alimentary system; brain; integumental system; lung; and reproductive system. Used to study several diseases, including autoimmune disease (multiple); congestive heart failure; heart valve disease (multiple); idiopathic pulmonary fibrosis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).
大鼠 Rat Tnf 分子靶点信息
- 分子名:Tnf, tumor necrosis factor
- 别称:
- cachectin
- LOC103694380
- MGC124630
- RATTNF
- TNF-a
- TNF-alpha
- Tnfa
- tumor necrosis factor (TNF superfamily, member 2)
- tumor necrosis factor alpha
- tumor necrosis factor ligand superfamily member 2
- tumor necrosis factor superfamily member 2
- tumor necrosis factor superfamily, member 2
- tumor necrosis factor-alpha
- tumor necrosis factor-like
- 基因序列:NCBI_Gene: 24835
- 蛋白序列:UniProtKB: P16599
大鼠 Rat Tnf 靶点分子功能(预测)
Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).
TNF 分子产品列表
-
- EK282EG
- 一步法ELISA试剂盒
EasyGo!™ Mouse TNF-α One-Step ELISA Kit EasyGo!™ 小鼠肿瘤坏死因子α (TNF-α) 一步法酶联免疫吸附测定试剂盒
- ¥2,190.00 – ¥3,650.00
-
- EK282S
- ELISA标准品
Mouse TNF-α Standard (小鼠TNF-α 标准品)
- ¥180.00
-
- F11TNFA02
- 流式抗体(新品), 流式抗体
Anti-Human TNF-α, PE(Clone:MAb11) (新品)
- ¥952.00 – ¥2,112.00
-
- EK282
- ELISA试剂盒
Mouse TNF-a ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK382HS
- ELISA试剂盒, 高敏试剂盒
Rat TNF-α High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
-
- EK382HSS
- 高敏试剂盒, ELISA标准品
Rat TNF-α High Sensitivity Standard (大鼠肿瘤坏死因子α高敏 标准品)
- ¥180.00
-
- EK382S
- ELISA标准品
Rat TNF-α Standard (大鼠肿瘤坏死因子α 标准品)
- ¥180.00
-
- EK382
- ELISA试剂盒
Rat TNF-a ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK282HS
- ELISA试剂盒, 高敏试剂盒
Mouse TNF-α High Sensitivity ELISA Kit
- ¥2,000.00 – ¥3,400.00
-
- EK282HSS
- 高敏试剂盒, ELISA标准品
Mouse TNF-α High Sensitivity Standard (小鼠TNF-α高敏 标准品)
- ¥180.00
-
- EK182S
- ELISA标准品
Human TNF-α Standard (人肿瘤坏死因子α (TNF-α) 标准品)
- ¥280.00
-
- EK182HSS
- 高敏试剂盒, ELISA标准品
Human TNF-α High Sensitivity Standard (人肿瘤坏死因子α高敏 标准品)
- ¥280.00
-
- EK182HS
- ELISA试剂盒, 高敏试剂盒
Human TNF-α High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
-
- EK182
- ELISA试剂盒
Human TNF-a ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00