Rat sICAM-1/CD54 Standard (大鼠细胞间粘附分子1 (ICAM-1) 标准品)

ICAM1 分子靶点信息概述

• 分子名：ICAM1, intercellular adhesion molecule 1
• 基因家族：CD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
• 别名：BB2; CD54
• 全称：human rhinovirus receptor

ICAM1 分子靶点综述

细胞间粘附分子1(ICAM-1)也称为CD54，是一个几乎无所不在的跨膜糖蛋白，通常表达于内皮细胞和免疫细胞，对白细胞迁移和活化具有关键作用。它与CD11a/CD18或CD11b/CD18型整合素结合，也会被鼻病毒作为受体利用。可溶性细胞间粘附分子1(sICAM-1)促进血管生成，可作为血管内皮细胞活化或受损的指示剂。它也可作为跨膜ICAM-1抑制剂，介导活性如单核细胞对活化的内皮细胞的黏附以及肿瘤细胞对NK细胞介导的溶解作用的敏感性。监测血清中的sICAM-1表达水平可对多种病理状态提供更加详细的视角，如心血管疾病、II型糖尿病、器官移植障碍、氧化应激、腹部脂肪团、高血压、肝脏疾病和某些恶性肿瘤等。

大鼠 Rat Icam1 分子靶点信息

• 分子名：Icam1, intercellular adhesion molecule 1
• 别称：
  • CD54
  • ICAM
  • ICAM-1
• 基因序列：NCBI_Gene: 25464
• 蛋白序列：UniProtKB: Q00238

大鼠 Rat Icam1 靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1).