Mouse sICAM-1/CD54 Standard (小鼠可溶性细胞间粘附分子1 (sICAM-1) 标准品)
¥280.00
文章目录[隐藏]
本产品只包含标准品试剂,如需购买试剂盒请点击下图
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- EK289 8 Citations
- ELISA试剂盒
Mouse sICAM-1/CD54 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
商品名 |
Mouse sICAM-1/CD54 Standard (小鼠可溶性细胞间粘附分子1 (sICAM-1) 标准品) |
---|---|
组分 |
大鼠IL-1β 标准品 |
板式 |
管 |
保存 |
短期4℃,长期-20℃保存 |
运输条件 |
4℃蓝冰运输 |
分子信息
ICAM1 分子靶点信息概述
- 分子名:ICAM1, intercellular adhesion molecule 1
- 基因家族:CD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
- 别名:BB2; CD54
- 全称:human rhinovirus receptor
ICAM1 分子靶点综述
细胞间粘附分子1(ICAM-1)也称为CD54,是一个几乎无所不在的跨膜糖蛋白,通常表达于内皮细胞和免疫细胞,对白细胞迁移和活化具有关键作用。它与CD11a/CD18或CD11b/CD18型整合素结合,也会被鼻病毒作为受体利用。可溶性细胞间粘附分子1(sICAM-1)促进血管生成,可作为血管内皮细胞活化或受损的指示剂。它也可作为跨膜ICAM-1抑制剂,介导活性如单核细胞对活化的内皮细胞的黏附以及肿瘤细胞对NK细胞介导的溶解作用的敏感性。监测血清中的sICAM-1表达水平可对多种病理状态提供更加详细的视角,如心血管疾病、II型糖尿病、器官移植障碍、氧化应激、腹部脂肪团、高血压、肝脏疾病和某些恶性肿瘤等。
小鼠 Mouse Icam1 分子靶点信息
- 分子名:Icam1, intercellular adhesion molecule 1
- 别称:
- CD54
- Icam-1
- Ly-47
- lymphocyte antigen 47
- MALA-2
- MGC:6195
- 基因序列:NCBI_Gene: 15894
- 蛋白序列:
小鼠 Mouse Icam1 靶点分子功能(预测)
Predicted to enable integrin binding activity. Acts upstream of or within several processes, including T cell antigen processing and presentation; cellular response to glucose stimulus; and cellular response to leukemia inhibitory factor. Located in external side of plasma membrane and immunological synapse. Colocalizes with membrane raft. Is expressed in several structures, including cardiovascular system; liver vasculature; lung; skin; and thymus primordium. Used to study malaria. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; inflammatory bowel disease (multiple); liver cirrhosis; and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1).