EK1154S

Human VEGF-C Standard (人血管内皮生长因子C 标准品)

¥280.00

  • 分子靶点:VEGFC, VEGF-C, VRP
  • 种属:人 (Human)
  • 试剂盒:EK1154
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1154S


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商品名

Human VEGF-C Standard (人血管内皮生长因子C 标准品)

组分

人VEGF-C冻干标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 VEGFC, VEGF-C, VRP 靶点信息

VEGFC 分子靶点信息概述

  • 分子名:VEGFC, vascular endothelial growth factor C
  • 基因家族:VEGF family
  • 别名:VRP; VEGF-C
  • 全称:vascular endothelial growth factor-related protein

VEGFC 分子靶点综述

血管内皮生长因子C(VEGF-C)是一种二聚体分泌型蛋白,PDGF/VEGF家族中的一员。翻译后的VEGF-C有三个结构域:中间的VEGF同源结构域(VHD)、N端结构域(前肽)和C端结构域(前肽)。VEGF-C对淋巴管的生成有重要作用,主要通过结合它的受体VEGFR-3来作用于淋巴管内皮细胞,从而促进其生存、生长和迁移。研究证明,VEGF-C是各种模型淋巴管的特定生长因子。VEGF-C除了对淋巴管有作用,它还可促进血管的生长并调节血管的通透性,是通过结合它的主要受体VEGFR-3或次级受体VEGFR-2来发挥作用的。另外,VEGF-C对神经发育和血压调节也具有重要作用。缺乏VEGF-C会导致淋巴水肿,而过量的VEGF-C与肿瘤血管生成和转移有关。

人 Human VEGFC 分子靶点信息

  • 分子名:VEGFC, vascular endothelial growth factor C
  • 别称:
    • FLT4 ligand DHM
    • Flt4-L
    • LMPH1D
    • LMPHM4
    • vascular endothelial growth factor-related protein
    • VEGF-C
    • VRP
  • 基因序列:NCBI_Gene: 7424
  • 蛋白序列:UniProtKB: P49767

人 Human VEGFC靶点分子功能(预测)

Enables chemoattractant activity and vascular endothelial growth factor receptor 3 binding activity. Involved in induction of positive chemotaxis; positive regulation of mast cell chemotaxis; and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Implicated in breast carcinoma and hereditary lymphedema ID. Biomarker of several diseases, including invasive ductal carcinoma; liver disease (multiple); papillary carcinoma; pterygium; and urinary system cancer (multiple).

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引用文献


  1. SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway 

  2. Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma 

  3. LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer 

  4. Synergistic effects of nanoattapulgite and hydroxyapatite on vascularization and bone formation in a rabbit tibia bone defect model 

  5. Cysteine protease inhibitor S promotes lymph node metastasis of esophageal cancer cells via VEGF-MAPK/ERK-MMP9/2 pathway 

  6. Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma 

  7. Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis