Human TREM2 Standard (人髓系细胞触发受体2 (TREM2) 标准品)

TREM2 分子靶点信息概述

• 分子名：TREM2, triggering receptor expressed on myeloid cells 2
• 基因家族：V-set domain containing
• 别名：TREM-2; Trem2a; Trem2b; Trem2c
• 全称：triggering receptor expressed on myeloid cells 2a

TREM2 分子靶点综述

髓系细胞触发受体2 (TREM2)是一个单一Ig结构域受体，它在巨噬细胞和树突状细胞中表达，但不在粒细胞或单核细胞中表达。它在基底节、胼胝体、延髓和脊髓中的表达最丰富，而中枢神经系统中的小胶质细胞是产生TREM2的最主要的细胞类型。TREM2在慢性炎症中发挥作用，可刺激组成的而非炎症的趋化因子和细胞因子产生。TREM2与TYROBP组成受体信号复合物来激活巨噬细胞和树突状细胞的免疫应答。它同样与衔接蛋白DAP12联系在一起来传递活化信号，该信号在先天性和适应性免疫应答中起作用。TREM2信号也是一个促进结肠伤口愈合的重要途径。TREM2突变会增加神经退行性疾病如阿尔茨海默氏病、肌萎缩侧索硬化症和帕金森氏病的风险。

人 Human TREM2 分子靶点信息

• 分子名：TREM2, triggering receptor expressed on myeloid cells 2
• 别称：
  • PLOSL2
  • TREM-2
  • Trem2a
  • Trem2b
  • Trem2c
  • triggering receptor expressed on monocytes 2
  • triggering receptor expressed on myeloid cells 2a
• 基因序列：NCBI_Gene: 54209
• 蛋白序列：UniProtKB: Q9NZC2

人 Human TREM2靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of signal transduction; and regulation of neuroinflammatory response. Acts upstream of with a positive effect on memory and social behavior. Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.