Human sCD40L Standard (人CD40配体 标准品)

CD40LG 分子靶点信息概述

• 分子名：CD40LG, CD40 ligand
• 基因家族：CD molecules; Tumor necrosis factor superfamily
• 别名：CD40L; TRAP; gp39; hCD40L; CD154
• 曾用名：HIGM1; IMD3; TNFSF5
• 全称：CD40 antigen ligand; tumor necrosis factor (ligand) superfamily member 5; T-B cell-activating molecule; TNF-related activation protein; hyper-IgM syndrome; tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)

CD40LG 分子靶点综述

CD40配体(CD40L/CD154)是TNF分子超家族中的一员，它是一种分子量为39kDa的糖蛋白，主要表达于活化的T细胞。分子量为15-18kDa的可溶性CD40L(sCD40L)通过蛋白水解产生。CD40L与抗原提呈细胞(APC)表面的CD40结合，根据不同的靶细胞类型可产生多种效果。CD40L作为共刺激分子，对T细胞亚群滤泡辅助性T细胞(Tfh细胞)尤其重要。在Tfh细胞中，CD40L与B细胞表面的CD40结合，促进B细胞成熟和功能发挥，从而促进细胞与细胞之间的联系。CD40L基因的缺失导致无法发生免疫球蛋白类型转换，且与高IgM综合征有关。CD40L缺失也会阻断生发中心形成，因此阻止适应性免疫系统中的重要过程即抗体亲和力成熟。

人 Human CD40LG 分子靶点信息

• 分子名：CD40LG, CD40 ligand
• 别称：
  • CD154
  • CD40 antigen ligand
  • CD40-L
  • CD40L
  • gp39
  • hCD40L
  • HIGM1
  • IGM
  • IMD3
  • T-B cell-activating molecule
  • T-BAM
  • T-cell antigen Gp39
  • TNF-related activation protein
  • TNFSF5
  • TRAP
  • tumor necrosis factor (ligand) superfamily member 5
• 基因序列：NCBI_Gene: 959
• 蛋白序列：UniProtKB: P29965

人 Human CD40LG靶点分子功能（预测）

Enables CD40 receptor binding activity and integrin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of apoptotic process. Located in cell surface. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Biomarker of several diseases, including allergic rhinitis; autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); and hematologic cancer (multiple).