CD40LG 靶点信息

CD40LG 分子靶点信息概述

  • 分子名：CD40LG, CD40 ligand
  • 基因家族：CD molecules; Tumor necrosis factor superfamily
  • 别名：CD40L; TRAP; gp39; hCD40L; CD154
  • 曾用名：HIGM1; IMD3; TNFSF5
  • 全称：CD40 antigen ligand; tumor necrosis factor (ligand) superfamily member 5; T-B cell-activating molecule; TNF-related activation protein; hyper-IgM syndrome; tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)

CD40LG 分子靶点综述

CD40配体(CD40L/CD154)是TNF分子超家族中的一员，它是一种分子量为39kDa的糖蛋白，主要表达于活化的T细胞。分子量为15-18kDa的可溶性CD40L(sCD40L)通过蛋白水解产生。CD40L与抗原提呈细胞(APC)表面的CD40结合，根据不同的靶细胞类型可产生多种效果。CD40L作为共刺激分子，对T细胞亚群滤泡辅助性T细胞(Tfh细胞)尤其重要。在Tfh细胞中，CD40L与B细胞表面的CD40结合，促进B细胞成熟和功能发挥，从而促进细胞与细胞之间的联系。CD40L基因的缺失导致无法发生免疫球蛋白类型转换，且与高IgM综合征有关。CD40L缺失也会阻断生发中心形成，因此阻止适应性免疫系统中的重要过程即抗体亲和力成熟。

CD40LG, CD40 ligand 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD40LG 分子靶点信息

  • 分子名：CD40LG, CD40 ligand
  • 别称：
    • CD154
    • CD40 antigen ligand
    • CD40-L
    • CD40L
    • gp39
    • hCD40L
    • HIGM1
    • IGM
    • IMD3
    • T-B cell-activating molecule
    • T-BAM
    • T-cell antigen Gp39
    • TNF-related activation protein
    • TNFSF5
    • TRAP
    • tumor necrosis factor (ligand) superfamily member 5
  • 基因序列：NCBI_Gene: 959
  • 蛋白序列：UniProtKB: P29965

人 Human CD40LG靶点分子功能（预测）

Enables CD40 receptor binding activity and integrin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of apoptotic process. Located in cell surface. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Biomarker of several diseases, including allergic rhinitis; autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); and hematologic cancer (multiple).

小鼠 Mouse Cd40lg 分子靶点信息

  • 分子名：Cd40lg, CD40 ligand
  • 别称：
    • CD154
    • CD40 antigen ligand
    • Cd40l
    • Cd40L
    • gp39
    • HIGM1
    • IMD3
    • Ly-62
    • Ly62
    • lymphocyte antigen 62
    • T-BAM
    • Tnfsf5
    • tumor necrosis factor (ligand) superfamily, member 5
  • 基因序列：NCBI_Gene: 21947
  • 蛋白序列：

小鼠 Mouse Cd40lg 靶点分子功能（预测）

Predicted to enable CD40 receptor binding activity and integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).

大鼠 Rat Cd40lg 分子靶点信息

  • 分子名：Cd40lg, CD40 ligand
  • 别称：
    • CD40 ligand CD154
    • CD40-L
    • Cd40l
    • LOC84349
    • Tnfsf5
    • tumor necrosis factor (ligand) superfamily, member 5
    • tumor necrosis factor ligand superfamily member 5
  • 基因序列：NCBI_Gene: 84349
  • 蛋白序列：

大鼠 Rat Cd40lg 靶点分子功能（预测）

Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand).

CD40LG 分子产品列表

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