Human Antithrombin-III/Serpin C1 Standard (人抗凝血酶III/丝氨酸蛋白酶抑制剂蛋白C1 标准品)

SERPINC1 分子靶点信息概述

• 分子名：SERPINC1, serpin family C member 1
• 基因家族：Serpin peptidase inhibitors
• 别名：ATIII; MGC22579
• 曾用名：AT3
• 全称：antithrombin III; signal peptide antithrombin part 1; coding sequence signal peptide antithrombin part 1; antithrombin (aa 375-432); serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1

SERPINC1 分子靶点综述

Antithrombin-III，是丝氨酸蛋白酶抑制剂 Serpin 超家族的成员，由 SerpinC1 基因所编码，研 究已发现 Antithrombin-III 是弥散性血管内凝血(DIC)的标志物。该蛋白可以抑制凝血酶和其他活化 丝氨酸蛋白酶凝血系统，调节凝血级联反应。Antithrombin-III 是最重要的凝血因子抑制剂，即使 Antithrombin-III 出现微小的变化，其也能 显著增加血栓栓塞的风险。Antithrombin-III 可以通过依赖性凝血效应或非依赖性凝血效应来抑制 炎症。此外，除了 Antithrombin-III 缺乏症外，Antithrombin-III 及其编码基因 SerpinC1 也可能与许多疾病(如高血压、肾脏疾病)相关。

人 Human SERPINC1 分子靶点信息

• 分子名：SERPINC1, serpin family C member 1
• 别称：
  • antithrombin III
  • antithrombin III isoform
  • antithrombin-III
  • AT3
  • AT3D
  • ATIII
  • ATIII-R2
  • ATIII-T1
  • ATIII-T2
  • MGC22579
  • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
  • serine-cysteine proteinase inhibitor clade C member 1
  • serpin C1
  • serpin peptidase inhibitor clade C member 1
  • serpin peptidase inhibitor, clade C (antithrombin), member 1
  • THPH7
• 基因序列：NCBI_Gene: 462
• 蛋白序列：UniProtKB: P01008

人 Human SERPINC1靶点分子功能（预测）

Enables identical protein binding activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Biomarker of acute kidney failure; nephrotic syndrome; osteonecrosis; and type 2 diabetes mellitus.