Human 4-1BB/TNFRSF9/CD137 Standard (人4-1BB 标准品)

TNFRSF9 分子靶点信息概述

• 分子名：TNFRSF9, TNF receptor superfamily member 9
• 基因家族：CD molecules; Tumor necrosis factor receptor superfamily
• 别名：CD137; 4-1BB
• 曾用名：ILA
• 全称：tumor necrosis factor receptor superfamily, member 9

TNFRSF9 分子靶点综述

4-1BB，也称为TNFRSF9或CD137，是肿瘤坏死因子超家族的受体。人4-1BB基因编码由255个氨基酸组成的I型跨膜蛋白，包含17个氨基酸的N端信号肽、169个氨基酸的胞外区、27个氨基酸的跨膜区和42个氨基酸的胞外区。重组人可溶性4-1BB是一个167氨基酸的多肽(17.7kDa)，包括富含胱氨酸TNFR样的4-1BB胞外区。4-1BB主要表达于各种T细胞的表面，在B细胞、单核细胞和多种转化细胞系中也有表达。该蛋白有助于克隆增殖、存活和T细胞发育。它也能诱导外周单核细胞的增殖，增强由TCR/CD3触发活化而诱导的T细胞凋亡，同时调节CD28共刺激促进Th1细胞应答。该蛋白的表达是通过淋巴细胞活化诱导。TRAF转接蛋白可与该蛋白结合，并转导激活NF-κB的信号。它还参与高脂肪食源性代谢综合症中炎症的发展。

人 Human TNFRSF9 分子靶点信息

• 分子名：TNFRSF9, TNF receptor superfamily member 9
• 别称：
  • 4-1BB
  • 4-1BB ligand receptor
  • CD137
  • CD137 antigen
  • CDw137
  • FLJ43501
  • homolog of mouse 4-1BB
  • ILA
  • induced by lymphocyte activation (ILA)
  • interleukin-activated receptor, homolog of mouse Ly63
  • MGC2172
  • receptor protein 4-1BB
  • T cell antigen ILA
  • T-cell antigen 4-1BB homolog
  • T-cell antigen ILA
  • tumor necrosis factor receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9
• 基因序列：NCBI_Gene: 3604
• 蛋白序列：UniProtKB: Q07011

人 Human TNFRSF9靶点分子功能（预测）

Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space. Predicted to be active in external side of plasma membrane.