Anti-Human CD223, FITC (Clone: OTI5D8)检测试剂
¥1,360.00 – ¥3,368.00
- 分子靶点:CD223, LAG3
- 种属:人 (Human)
- 标记:FITC
- 亚型:Mouse IgG1
- 克隆号:OTI5D8
在售SKU, F1122301, 70-F1122301-100, 70-F1122301-25
商品名 |
Anti-Human CD223, FITC (Clone: OTI5D8)检测试剂 |
---|---|
靶点 | |
标记 |
FITC |
仪器 |
适用488nm激光器的流式细胞仪 |
亚型 |
Mouse IgG1 |
克隆号 |
OTI5D8 |
推荐应用 |
流式检测 |
用量 |
5 μL/Test |
纯化 |
亲和层析 |
储存液 |
含 0.2% BSA 和0.2% proclin 950 的磷酸盐缓冲液(pH7.2) |
保存条件 |
2 - 8℃避光,切勿冻存 |
结果示例


图 - CD3、CD28抗体诱导的人PBMC染色左图为Mouse IgG1 Isotype control, FITC和Anti-Human CD4, APC的结果,右图为Anti-Human CD223, FITC(F1122301)和Anti-Human CD4, APC的结果,以全部细胞设门。
分子信息
LAG3 分子靶点信息概述
- 分子名:LAG3, lymphocyte activating 3
- 基因家族:CD molecules; Immunoglobulin like domain containing
- 别名:CD223
- 全称:lymphocyte-activation gene 3
LAG3 分子靶点综述
CD223,即淋巴细胞活化基因3(LAG-3),其结合MHC-II比CD4具有更高亲和力,所以被认为与T细胞活化的负调控以及稳态增殖有关。LAG-3有报道说在活化的T细胞(包括调节性T细胞)以及NK细胞上表达。CD8+T细胞上通常比CD4+T细胞表达更多的LAG-3。 LAG-3与CD49b的共表达被推荐用于鉴定人和小鼠的Tr1细胞。
人 Human LAG3 分子靶点信息
- 分子名:LAG3, lymphocyte activating 3
- 别称:
- CD223
- lymphocyte activation gene 3 protein
- lymphocyte-activation gene 3
- 基因序列:NCBI_Gene: 3902
- 蛋白序列:UniProtKB: P18627
人 Human LAG3靶点分子功能(预测)
Enables MHC class II protein binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular region.