Use of Immune Modulation by Human Adipose-Derived Mesenchymal Stem Cells to Treat Experimental Arthritis in Mice

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作者：Zhang, L., Wang, X. Y., Zhou, P. J., He, Z., Yan, H. Z., Xu, D. D., Wang, Y., Fu, W. Y., Ruan, B. B., Wang, S., Chen, H. X., Liu, Q. Y., Zhang, Y. X., Liu, Z. & Wang, Y. F.
期刊：American journal of translational research 9, 2595-2607 (2017)
阅读原文

Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammatory cell infiltration and joint erosion. Human adipose-derived mesenchymal stem cells (hASCs) have shown the capacity of suppressing effector T cell activation and inflammatory cytokine expression. We investigated whether hASCs play a therapeutic role in collagen-induced arthritis (CIA) by administering a single dose of hASCs in mice with established CIA. In vivo, a beneficial effect was observed following hASC infusion as shown by a marked decrease in the severity of arthritis. Human ASCs were detectable in the joints, and reduced levels of pro-inflammatory cytokines and increased levels of anti-inflammatory cytokines were observed in the sera of the hASC-treated mice. Furthermore, hASC treatment induced the expansion of regulatory T cells (Tregs) both in the peripheral blood and in the spleen tissues. In vitro, hASCs downregulated the production of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in mouse macrophages stimulated with lipopolysaccharide and inhibited the proliferation of human primary T cells in response to mitogens. Thus hASCs represent a novel and effective therapeutic strategy for RA.