肿瘤代谢——Novus脂类代谢研究系列4

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https://www.liankebio.com/article-information_Newsletter-958.html

作者:Novus官网 发布日期:2014-11-01 08:00

肿瘤细胞最重要的生物学特征是无限制的快速增殖,为了满足其快速增殖的需要,肿瘤细胞表现出与正常细胞不同的代谢特征。早在1924年Otto Warhurg就发现肿瘤细胞在葡萄糖的利用上与正常细胞不同,即肿瘤细胞更喜欢将葡萄糖进行糖酵解转变为乳酸,而不是像正常细胞那样经三羧酸循环(TCA cycle)由线粒体氧化磷酸化产生三磷酸腺苷(ATP),即使在氧气充足的情况下也是如此。最早对此现象的解释是Warburg本人于1956年提出,而后来研究者发现在大多数肿瘤细胞中线粒体的功能并未受损,说明Warburg现象是由其他原因造成的。随着人们对肿瘤研究的逐步深入,肿瘤细胞的代谢途径以及调控已经得到初步阐明。

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相关指标
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产品引用文献:

1.[ADFP Antibody NB110-40877] Wohlers LM, Jackson KC, Spangenburg EE. Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. J Cell Biochem. 2011 Aug 3. [PMID: 21815195]

2.[ARH Antibody NB100-1276] Ye Z-J, Go G-W, Singh R, et al. LRP6 regulates LDLR-mediated LDL uptake. The Journal of Biological Chemistry. 2011 Nov 28. [PMID: 22128165]

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4.[Cytochrome P450 17A1 Antibody NB100-92420] Jeong CW, Yoon CY, Jeong SJ, et al. Limited expression of cytochrome p450 17[alpha]-hydroxylase/17,20-lyase in prostate cancer cell lines.Korean J Urol. 2011 Jul;52(7):494-497. [PMID: 21860772]

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6.[OSBP1 Antibody NB100-1500, OSBPL10 Antibody NB100-2448, OSBPL11 Antibody NB100-1337,OSBPL2 Antibody NB100-1332 and OSBPL9 Antibody NB100-1336] Storey SM, McIntosh AL, Huang H, et al.

7.Intracellular Cholesterol Binding Proteins Enhance HDL-mediated Cholesterol Uptake in Cultured Primary Mouse Hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2012 Jan 12.

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9.[PDK1 Antibody NB100-2383] Luo W, Hu H, Chang R, et al. Pyruvate Kinase M2 is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1.Cell. 2011 May 27;145(5):732-44. [PMID: 21620138]

10.[PDK1 Antibody NB100-2384] Lin HP, Jiang SS, Chuu CP. Caffeic Acid Phenethyl Ester Causes p21 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells. PLoS One. 2012;7(2):e31286. [PMID: 22347457]联科生物代理截止时间:2017年6月30日