EK1161S

Human TRAIL/TNFSF10 Standard (人肿瘤坏死因子相关的凋亡诱导配体 (TRAIL) 标准品)

¥280.00

分子靶点：TNFSF10, TRAIL, TL2, CD253
种属：人 (Human)
试剂盒：EK1161
保存：短期4℃保存，长期-20℃保存
运输条件：4℃蓝冰运输

在售SKU:70-EK1161S

文章目录[隐藏]

本产品只包含标准品试剂，如需购买试剂盒请点击下图
Human TRAIL/TNFSF10 ELISA Kit检测试剂盒（酶联免疫吸附法）
分子信息
TNFSF10 分子靶点信息概述
TNFSF10 分子靶点综述
- 人 Human TNFSF10 分子靶点信息
- 人 Human TNFSF10靶点分子功能（预测）

本产品只包含标准品试剂，如需购买试剂盒请点击下图

- EK1161 2 Citations
- ELISA试剂盒
- Human TRAIL/TNFSF10 ELISA Kit检测试剂盒（酶联免疫吸附法）
- ¥1,600.00 – ¥2,650.00

商品名	Human TRAIL/TNFSF10 Standard (人肿瘤坏死因子相关的凋亡诱导配体 (TRAIL) 标准品)
组分	人TRAIL/TNFSF10 标准品
板式	管
保存	短期4℃，长期-20℃保存
运输条件	4℃蓝冰运输

分子信息

概述人 TNFSF10, TRAIL, TL2, CD253 靶点信息

TNFSF10 分子靶点信息概述

分子名：TNFSF10, TNF superfamily member 10
基因家族：CD molecules; Tumor necrosis factor superfamily
别名：TRAIL; Apo-2L; TL2; CD253
全称：tumor necrosis factor (ligand) superfamily, member 10

TNFSF10 分子靶点综述

肿瘤坏死因子相关的凋亡诱导配体(TRAIL)也称为CD253或TNFSF10，可由大部分正常组织细胞产生并分泌。TRAIL与死亡受体DR4(TRAIL-RI)和DR5(TRAIL-RII)结合。凋亡的过程依赖于caspase-8。Caspase-8活化下游的caspase，包括procaspase-3、6和7，使特异性的激酶活化。TRAIL也能与不含胞浆区的受体DcR1和含有截短的死亡结构域的受体DcR2结合。DcR1可作为TRAIL中和受体。DcR2的胞浆区具有功能，可活化NF-κB。因此在表达DcR2的细胞中，TRAIL的结合会活化NF-κB，使拮抗死亡信号通路和/或促进炎症的基因发生转录。

人 Human TNFSF10 分子靶点信息

分子名：TNFSF10, TNF superfamily member 10
别称：
- Apo-2 ligand
- Apo-2L
- APO2L
- CD253
- chemokine tumor necrosis factor ligand superfamily member 10
- TL2
- TNF-related apoptosis inducing ligand TRAIL
- TNF-related apoptosis-inducing ligand
- TNLG6A
- TRAIL
- tumor necrosis factor (ligand) family, member 10
- tumor necrosis factor (ligand) superfamily member 10
- tumor necrosis factor (ligand) superfamily, member 10
- tumor necrosis factor apoptosis-inducing ligand splice variant delta
- tumor necrosis factor ligand 6A
- tumor necrosis factor ligand superfamily member 10
- tumor necrosis factor superfamily member 10
基因序列：NCBI_Gene: 8743
蛋白序列：UniProtKB: P50591

人 Human TNFSF10靶点分子功能（预测）

Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.