Human TRAIL/TNFSF10 Standard (人肿瘤坏死因子相关的凋亡诱导配体 (TRAIL) 标准品)

TNFSF10 分子靶点信息概述

• 分子名：TNFSF10, TNF superfamily member 10
• 基因家族：CD molecules; Tumor necrosis factor superfamily
• 别名：TRAIL; Apo-2L; TL2; CD253
• 全称：tumor necrosis factor (ligand) superfamily, member 10

TNFSF10 分子靶点综述

肿瘤坏死因子相关的凋亡诱导配体(TRAIL)也称为CD253或TNFSF10，可由大部分正常组织细胞产生并分泌。TRAIL与死亡受体DR4(TRAIL-RI)和DR5(TRAIL-RII)结合。凋亡的过程依赖于caspase-8。Caspase-8活化下游的caspase，包括procaspase-3、6和7，使特异性的激酶活化。TRAIL也能与不含胞浆区的受体DcR1和含有截短的死亡结构域的受体DcR2结合。DcR1可作为TRAIL中和受体。DcR2的胞浆区具有功能，可活化NF-κB。因此在表达DcR2的细胞中，TRAIL的结合会活化NF-κB，使拮抗死亡信号通路和/或促进炎症的基因发生转录。

人 Human TNFSF10 分子靶点信息

• 分子名：TNFSF10, TNF superfamily member 10
• 别称：
  • Apo-2 ligand
  • Apo-2L
  • APO2L
  • CD253
  • chemokine tumor necrosis factor ligand superfamily member 10
  • TL2
  • TNF-related apoptosis inducing ligand TRAIL
  • TNF-related apoptosis-inducing ligand
  • TNLG6A
  • TRAIL
  • tumor necrosis factor (ligand) family, member 10
  • tumor necrosis factor (ligand) superfamily member 10
  • tumor necrosis factor (ligand) superfamily, member 10
  • tumor necrosis factor apoptosis-inducing ligand splice variant delta
  • tumor necrosis factor ligand 6A
  • tumor necrosis factor ligand superfamily member 10
  • tumor necrosis factor superfamily member 10
• 基因序列：NCBI_Gene: 8743
• 蛋白序列：UniProtKB: P50591

人 Human TNFSF10靶点分子功能（预测）

Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.