Anti-Human IL-2, mFluor 610 (Clone: MQ1-17H12) 检测试剂
¥702.00 – ¥2,810.00
- 分子靶点:IL2, IL-2
- 种属:人 (Human)
- 标记:mFlour 610
- 亚型:Rat IgG2a, κ
- 克隆号:MQ1-17H12
在售SKU,70-F110I209-25, 70-F110I209-100
| 商品名 | Anti-Human IL-2, mFluor 610 (Clone: MQ1-17H12) 检测试剂 | 
|---|---|
| 靶点 | |
| 标记 | mFlour 610 | 
| 仪器 | 适用405nm激光器的流式细胞仪 | 
| 亚型 | Rat IgG2a, κ | 
| 克隆号 | MQ1-17H12 | 
| 推荐应用 | 流式检测 | 
| 用量 | 5 μL /Test | 
| 纯化 | 亲和层析 | 
| 储存液 | 含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2) | 
| 保存条件 | 2 - 8℃避光,切勿冻存 | 
结果示例


图 - 正常人的外周血样本用细胞刺激阻断剂(目录号:CS1001和CS1002)预处理,固定破膜剂(目录号:GAS003/2)破膜后进行染色,左图为Rat IgG2a, κ Isotype control, mFluor 610和Anti-Human CD3,APC共染的结果,右图为Anti-Human IL-2, mFluor 610和Anti-Human CD3, APC共染的结果。以淋巴细胞设门进行分析。
分子信息
IL2 分子靶点信息概述
- 分子名:IL2, interleukin 2
- 基因家族:Interleukins
- 别名:IL-2; TCGF
- 全称:T cell growth factor
IL2 分子靶点综述
白细胞介素2(IL-2)是15kDa的糖蛋白,在人类中,由位于4号染色体q26–28区域的单基因编码。它是免疫系统中的一类信号分子,调控对具有免疫功能的白血球(白细胞,通常是淋巴细胞)的活性。IL-2是机体对微生物感染的天然应答,区别外来和自身抗原。IL-2通过与IL-2受体来发挥功能,其受体由3条链组成,分别为α链(CD25)、β链(CD122)和γ链(CD132)。监测血清中的IL-2含量为多种病理状态提供更详细的视角,包括癌症、传染病、移植排斥、多发性硬化症、类风湿性关节炎、系统性红斑狼疮和I型糖尿病等。
人 Human IL2 分子靶点信息
- 分子名:IL2, interleukin 2
- 别称:
- aldesleukin
- IL-2
- interleukin-2
- involved in regulation of T-cell clonal expansion
- lymphokine
- T cell growth factor
- TCGF
 
- 基因序列:NCBI_Gene: 3558
- 蛋白序列:UniProtKB: P60568
人 Human IL2靶点分子功能(预测)
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in leukocyte activation involved in immune response; positive regulation of interleukin-17 production; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of activated T cell proliferation. Predicted to be located in extracellular space. Implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including Zellweger syndrome; aggressive periodontitis; anogenital venereal wart; autoimmune disease (multiple); and uveitis (multiple).
 
								

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