Arctigenin Protects against Liver Injury from Acute Hepatitis by Suppressing Immune Cells in Mice

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作者：Cheng, X., Wang, H., Yang, J., Cheng, Y., Wang, D., Yang, F., Li, Y., Zhou, D., Wang, Y., Xue, Z., Zhang, L., Zhang, Q., Yang, L., Zhang, R. & Da, Y.
期刊：Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 102, 464-471 (2018)
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As a phenylpropanoid and dibenzylbutyrolactone lignan present in medical plants, such as those used in traditional Chinese herbal medicine, including Arctium lappa (Niubang), arctigenin exhibits antimicrobial, anti-inflammatory, and anticancer activities. In this study, we investigated the protective role of arctigenin in Concanavalin A (ConA)-induced acute hepatitis in mice. Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo. The infiltration of CD4 T, NKT and macrophages into the livers was found to be reduced with arctigenin treatment. Arctigenin suppressed ConA-induced T lymphocyte proliferations that might have resulted from enhanced IL-10 production by macrophages and CD4 T cells. These results suggested that arctigenin could be a powerful drug candidate for acute hepatitis through immune suppression.