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白细胞介素 12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人 B 淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12 是一个由 2 种独立基因 IL-12A (p35)和 IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体 p40。
IL12A 分子靶点信息概述
- 分子名：IL12A, interleukin 12A
- 基因家族：Interleukins
- 别名：CLMF; IL-12A; p35; NFSK
- 曾用名：NKSF1
- 全称：nterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation factor 1, p35; interleukin 12, p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; interleukin-12 alpha chain; IL35 subunit
IL12B 分子靶点综述
白细胞介素12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人B淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12由4个а螺旋组成，是一个由2种独立基因--- IL-12A (p35)和IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体p40。IL-12参与初始T细胞向Th1细胞分化的过程，作为T细胞刺激因子，它可刺激T细胞的生长及其功能发挥。IL-12具有抗血管生成活性，对自然杀伤细胞和T淋巴细胞活性有重要作用。同样地，IL-12与自身免疫相关。
IL12, interleukin 12 分子靶点种属信息
人 Human IL12A 分子靶点信息
- 分子名：IL12A, interleukin 12A
- 别称：
- CLMF
- CLMF p35
- cytotoxic lymphocyte maturation factor 1, p35
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- IL-12 subunit p35
- IL-12, subunit p35
- IL-12A
- IL35 subunit
- interleukin 12, p35
- interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
- interleukin-12 alpha chain
- interleukin-12 subunit alpha
- natural killer cell stimulatory factor 1, 35 kD subunit
- NF cell stimulatory factor chain 1
- NFSK
- NK cell stimulatory factor chain 1
- NKSF1
- P35
- 基因序列：NCBI_Gene: 3592
- 蛋白序列：UniProtKB: P29459
人 Human IL12A靶点分子功能（预测）
Enables interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Contributes to cytokine activity and growth factor activity. Involved in several processes, including positive regulation of leukocyte mediated cytotoxicity; positive regulation of lymphocyte proliferation; and response to bacterium. Acts upstream of or within negative regulation of protein secretion. Located in extracellular space. Part of interleukin-12 complex. Implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Biomarker of hepatitis C.
小鼠 Mouse Il12a 分子靶点信息
- 分子名：Il12a, interleukin 12a
- 别称：
- Il-12a
- IL-12p35
- p35
- 基因序列：NCBI_Gene: 16159
- 蛋白序列：
小鼠 Mouse Il12a 靶点分子功能（预测）
Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Involved in positive regulation of T cell proliferation. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of type II interferon production. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).
大鼠 Rat Il12a 分子靶点信息
- 分子名：Il12a, interleukin 12A
- 别称：
- CLMF p35
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- IL-12 subunit p35
- IL-12A
- interleukin 12 p35 subunit
- interleukin-12 subunit alpha
- 基因序列：NCBI_Gene: 84405
- 蛋白序列：
大鼠 Rat Il12a 靶点分子功能（预测）
Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface; cytoplasm; and extracellular space. Predicted to be part of interleukin-12 complex. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).
大鼠 Rat Il12b 分子靶点信息
- 分子名：Il12b, interleukin 12B
- 别称：
- Il12
- Interleukin 12
- interleukin-12 p40
- interleukin-12 p40 precursor
- interleukin-12 subunit beta
- 基因序列：NCBI_Gene: 64546
- 蛋白序列：
大鼠 Rat Il12b 靶点分子功能（预测）
Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).
