IL-12 靶点信息

白细胞介素 12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人 B 淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12 是一个由 2 种独立基因 IL-12A (p35)和 IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体 p40。

IL12A 分子靶点信息概述IL12B 分子靶点信息概述

IL12A 分子靶点信息概述

  • 分子名：IL12A, interleukin 12A
  • 基因家族：Interleukins
  • 别名：CLMF; IL-12A; p35; NFSK
  • 曾用名：NKSF1
  • 全称：nterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation factor 1, p35; interleukin 12, p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; interleukin-12 alpha chain; IL35 subunit

IL12B 分子靶点信息概述

  • 分子名：IL12B, interleukin 12B
  • 基因家族：Immunoglobulin like domain containing; Interleukins
  • 别名：CLMF; IL-12B; NKSF; CLMF2
  • 曾用名：NKSF2
  • 全称：natural killer cell stimulatory factor-2; cytotoxic lymphocyte maturation factor 2, p40; interleukin 12, p40; natural killer cell stimulatory factor, 40 kD subunit; interleukin-12 beta chain; IL12, subunit p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

IL12B 分子靶点综述

白细胞介素12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人B淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12由4个а螺旋组成，是一个由2种独立基因--- IL-12A (p35)和IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体p40。IL-12参与初始T细胞向Th1细胞分化的过程，作为T细胞刺激因子，它可刺激T细胞的生长及其功能发挥。IL-12具有抗血管生成活性，对自然杀伤细胞和T淋巴细胞活性有重要作用。同样地，IL-12与自身免疫相关。

IL12, interleukin 12 分子靶点种属信息

人 Human IL1A人 Human IL1B小鼠 Mouse Il12a小鼠 Mouse Il12b大鼠 Rat Il12a大鼠 Rat Il12b

人 Human IL12A 分子靶点信息

  • 分子名：IL12A, interleukin 12A
  • 别称：
    • CLMF
    • CLMF p35
    • cytotoxic lymphocyte maturation factor 1, p35
    • cytotoxic lymphocyte maturation factor 35 kDa subunit
    • IL-12 subunit p35
    • IL-12, subunit p35
    • IL-12A
    • IL35 subunit
    • interleukin 12, p35
    • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
    • interleukin-12 alpha chain
    • interleukin-12 subunit alpha
    • natural killer cell stimulatory factor 1, 35 kD subunit
    • NF cell stimulatory factor chain 1
    • NFSK
    • NK cell stimulatory factor chain 1
    • NKSF1
    • P35
  • 基因序列：NCBI_Gene: 3592
  • 蛋白序列：UniProtKB: P29459

人 Human IL12A靶点分子功能（预测）

Enables interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Contributes to cytokine activity and growth factor activity. Involved in several processes, including positive regulation of leukocyte mediated cytotoxicity; positive regulation of lymphocyte proliferation; and response to bacterium. Acts upstream of or within negative regulation of protein secretion. Located in extracellular space. Part of interleukin-12 complex. Implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Biomarker of hepatitis C.

人 Human IL12B 分子靶点信息

  • 分子名：IL12B, interleukin 12B
  • 别称：
    • CLMF
    • CLMF p40
    • CLMF2
    • cytotoxic lymphocyte maturation factor 40 kDa subunit
    • IL-12 subunit p40
    • IL-12B
    • IL12, subunit p40
    • IMD28
    • IMD29
    • interleukin 12, p40
    • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2
    • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
    • interleukin-12 beta chain
    • interleukin-12 subunit beta
    • natural killer cell stimulatory factor, 40 kD subunit
    • NK cell stimulatory factor chain 2
    • NKSF
    • NKSF2
  • 基因序列：NCBI_Gene: 3593
  • 蛋白序列：UniProtKB: P29460

人 Human IL12B靶点分子功能（预测）

Enables identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte proliferation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of cytokine production. Acts upstream of or within negative regulation of protein secretion. Part of interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Biomarker of anogenital venereal wart.

小鼠 Mouse Il12a 分子靶点信息

小鼠 Mouse Il12a 靶点分子功能（预测）

Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Involved in positive regulation of T cell proliferation. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of type II interferon production. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).

小鼠 Mouse Il12b 分子靶点信息

小鼠 Mouse Il12b 靶点分子功能（预测）

Enables identical protein binding activity and interleukin-12 alpha subunit binding activity. Contributes to cytokine activity and cytokine receptor binding activity. Involved in positive regulation of T cell mediated cytotoxicity; positive regulation of T-helper 1 type immune response; and positive regulation of defense response to virus by host. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of interferon-gamma production. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex and interleukin-23 complex. Is expressed in colon. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).

大鼠 Rat Il12a 分子靶点信息

  • 分子名：Il12a, interleukin 12A
  • 别称：
    • CLMF p35
    • cytotoxic lymphocyte maturation factor 35 kDa subunit
    • IL-12 subunit p35
    • IL-12A
    • interleukin 12 p35 subunit
    • interleukin-12 subunit alpha
  • 基因序列：NCBI_Gene: 84405
  • 蛋白序列：

大鼠 Rat Il12a 靶点分子功能（预测）

Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface; cytoplasm; and extracellular space. Predicted to be part of interleukin-12 complex. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).

大鼠 Rat Il12b 分子靶点信息

大鼠 Rat Il12b 靶点分子功能（预测）

Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).

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