文章目录[隐藏]
CFD 分子靶点信息概述
- 分子名：CFD, complement factor D
- 基因家族：Granule associated serine proteases of immune defence; Complement system activation components
- 别名：ADN
- 曾用名：DF; PFD
- 全称：adipsin; D component of complement (adipsin); properdin factor D; complement factor D (adipsin)
CFD 分子靶点综述
补体因子D，即D因子，又称脂肪酶，是一种丝氨酸蛋白酶，是激活补体旁路途经所必需的。D因子是胰蛋白酶家族的肽酶的成员，在人类中由CFD基因编码。D因子在多种组织中表达，包括单核细胞/巨噬细胞、肌肉、坐骨神经、子宫内膜、肾脏、肠道，尤其在脂肪细胞中高水平表达。在肾功能衰竭患者中，循环的D因子浓度升高。类似地，在范科尼综合征患者中，肾脏的近端肾小管功能受损，尿液D因子浓度也处于高水平。
CFD, complement factor D 分子靶点种属信息
人 Human CFD 分子靶点信息
- 分子名：CFD, complement factor D
- 别称：
- ADIPSIN
- ADN
- C3 convertase activator
- complement factor D (adipsin)
- complement factor D preproprotein
- D component of complement (adipsin)
- DF
- PFD
- properdin factor D
- 基因序列：NCBI_Gene: 1675
- 蛋白序列：UniProtKB: P00746
人 Human CFD靶点分子功能（预测）
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation. Predicted to act upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular exosome. Biomarker of obesity.
小鼠 Mouse Cfd 分子靶点信息
- 分子名：Cfd, complement factor D (adipsin)
- 别称：
- adipsin
- Adn
- D component (adipsin) of complement
- DF
- factor D
- 基因序列：NCBI_Gene: 11537
- 蛋白序列：
小鼠 Mouse Cfd 靶点分子功能（预测）
Predicted to enable endopeptidase activity. Acts upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular space. Is expressed in adipose tissue; brown fat; epididymal fat pad; and white fat. Orthologous to human CFD (complement factor D).
大鼠 Rat Cfd 分子靶点信息
- 分子名：Cfd, complement factor D
- 别称：
- adipsin
- Adn
- C3 convertase activator
- complement factor D (adipsin)
- D component of complement (adipsin)
- Df
- endogenous vascular elastase
- EVE
- properdin factor D
- 基因序列：NCBI_Gene: 54249
- 蛋白序列：
大鼠 Rat Cfd 靶点分子功能（预测）
Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D).
