文章目录[隐藏]
CD6 分子靶点信息概述
- 分子名：CD6, CD6 molecule
- 基因家族：Scavenger receptor cysteine rich domain containing; CD molecules
- 别名：Tp120
- 曾用名：CD6 antigen
CD6 分子靶点综述
分化簇6（CD6,亦称TP120）是一种单次跨膜的I型膜蛋白，其结构中含有三个SRCR结构域。该细胞表面糖蛋白主要表达于T细胞，可作为共刺激分子参与自身反应性免疫应答。CD6在胸腺细胞、成熟T细胞、B细胞亚群（B-1细胞）及部分脑细胞中均有表达。
研究已鉴定出CD6的配体CD166（曾用名：活化白细胞粘附分子ALCAM），该配体表达于活化的T细胞、B细胞、胸腺上皮细胞、角质形成细胞及类风湿性关节炎滑膜组织。CD6通过与活化白细胞粘附分子（CD166）结合，作为共刺激分子参与淋巴细胞活化与胸腺细胞发育过程。
在T淋巴细胞中，CD6部分与TCR/CD3复合体结合，并在成熟免疫突触（IS）中心与其共定位。胸腺发育过程中，CD6依赖性信号不仅促进胸腺细胞存活，还在人类和小鼠的选择过程中调控整体功能亲和力。
CD6, CD6 molecule 分子靶点种属信息
人 Human CD6 分子靶点信息
- 分子名：CD6, CD6 molecule
- 别称：
- CD6 antigen
- FLJ44171
- T-cell differentiation antigen CD6
- T12
- TP120
- 基因序列：NCBI_Gene: 923
- 蛋白序列：UniProtKB: P30203
人 Human CD6 靶点分子功能（预测）
Enables identical protein binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; lipopolysaccharide-mediated signaling pathway; and positive regulation of cytokine production involved in inflammatory response. Located in T cell receptor complex and immunological synapse.
小鼠 Mouse CD6 分子靶点信息
- 分子名：Cd6, CD6 antigen
- 别称：
- OX52
- 基因序列：NCBI_Gene: 12511
- 蛋白序列：
小鼠 Mouse CD6 靶点分子功能（预测）
Predicted to enable several functions, including identical protein binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; lipopolysaccharide-mediated signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be located in cell surface and immunological synapse. Predicted to be part of T cell receptor complex. Orthologous to human CD6 (CD6 molecule).
大鼠 Rat CD6 分子靶点信息
- 分子名：Cd6, CD6 antigen
- 别称：
- CD6 antigen
- CD6 antigen Tp120
- CD6 antigen, Tp120
- LOC100911366
- MGC108551
- OX52
- T-cell differentiation antigen CD6
- T-cell differentiation antigen CD6-like
- 基因序列：NCBI_Gene: 25752
- 蛋白序列：
大鼠 Rat CD6 靶点分子功能（预测）
Enables protein kinase binding activity. Involved in positive regulation of protein phosphorylation. Located in cell surface. Orthologous to human CD6 (CD6 molecule).
CD6 分子产品列表
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- EK2D06EG
- 一步法ELISA试剂盒
EasyGo!™ Mouse CD6 One-Step ELISA Kit 检测试剂盒（酶联免疫吸附法）
- ¥2,190.00 – ¥3,650.00
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