PeproTech 高品质趋化因子 (Chemokine)

Post published:2017-04-01
Post category:生物资讯
Post views:3983 次访问

https://www.liankebio.com/article-information_Newsletter-1668.html

作者：PeproTech 官网发布日期：2017-04-01 09:00

趋化因子是一组具有趋化作用的细胞因子，能吸引免疫细胞到免疫应答局部，参与免疫调节和免疫病理反应。它们多为小于100个氨基酸的小分子多肽，根据结构可主要分为4个趋化因子亚家族：Cys-X-Cys(CXC)、Cys-Cys(CC)、Cys(C)、Cys-X3-Cys(CX3C) 亚家族（如下图）。CXC家族成员多数基因定位于第4对染色体，包括IL-8、IP-10(IFN inducible protein-10)、MGSA等，CC家族成员多数基因定位于第17对染色体，包括MIP-1α, β(macrophage inflammatory protein)、 MCP-1(macrophage chemotactic protein)、RANTES (regulated upon activation normal T expressed and secreted)等。C家族只有一个成员Lymphotactin，基因定位于1号染色体。CX3C家族也只有一个成员Fractalkine (neurotactin)，基因定位于第16对染色体。

PeproTech Chemokine(趋化因子)产品一览表

系统名称	功能名称（小鼠蛋白）	应答细胞（小鼠蛋白）	已知受体	产品货号
CXC Chemokines
CXCL1	GRO1, GRO-α, MGSA, NAP-3 (KC)	PMN	CXCR1, CXCR2	300-11/400-10/250-11
CXCL2	GRO2, GRO-β, MIP2-α (MIP-2)	PMN	CXCR1, CXCR2	300-39/400-11/250-15
CXCL3	GRO3, GRO-γ, MIP2-β (DCIP-1)	PMN	CXCR2	300-40
CXCL4	PF-4, Oncostatin-A	PMN, Mo	CXCR3B	300-16/250-39
CXCL5	ENA-78	PMN	CXCR2	300-22/300-22B
CXCL6	GCP-2, CKA-3 (LIX)	PMN	CXCR1, CXCR2	300-41/250-36/250-17
CXCL7	NAP-2, PBP, LDGF, MDGF	PMN	CXCR1, CXCR2	300-14
CXCL8	IL-8, GCP-1, NAP-1	PMN, Bs	CXCR1, CXCR2	200-08/200-08M
CXCL9	MIG	actT [Th1], NK	CXCR3	300-26/250-18
CXCL10	IP-10 (CRG-2)	Mo, actT [Th1], NK	CXCR3	300-12/250-16/400-33
CXCL11	I-TAC, IP-9	actT [Th1], NK	CXCR3, CXCR7	300-46/250-29
CXCL12	SDF-1, SDF-1α/β, PBSF	All cell types	CXCR4, CXCR7	300-28A/250-20A/400- 32A/300-28B/250-20B/ 400-32B
CXCL13	BCA-1, BLC	B, (Mo)	CXCR5	300-47/250-24
CXCL14	BRAK, MIP-2G	PMN, mDC (B, Mo)	unknown	300-50
CXCL15	(Lungkine)	PMN	unknown	250-37
CXCL16	SR-PSOX	actT	CXCR6	300-55/250-28
CXCL17	VEGF co-regulated chemokine 1, DMC	Mo, iDC	unknown
C Chemokines
XCL1	Lymphotactin, ATAC, SCM-1	Tr	XCR1	300-20
XCL2	SCM-1β	Tr	XCR1
CX3C Chemokine
CX3CL1	Fractalkine, Neurotactin, CX3C	Mo, actT, NK	CX3CR1	300-31/400-26
CC Chemokines
CCL1	I-309 (TCA-3)	iDC, actT [Th2], Mo (PMN)	CCR8	300-37
CCL2	MCP-1, MCAF, JE	Bs, Mo, actT, NK, iDC	CCR2, CCR4	300-04/250-10/400-12
CCL3	MIP-1α, LD78α	Eo, Mo, actT, NK, iDC (PMN)	CCR1,CCR4, CCR5	300-08/250-09/400-15
CCL3L1	LD78β	Mo, actT, B	CCR1,CCR3, CCR5	300-56
CCL4	MIP-1β , LAG-1	Mo, actT [Th1], NK, iDC	CCR5	300-09/250-32/400-09
CCL4L1	LAG-1 gene duplication	Mo	CCR1, CCR5	300-58
CCL5	RANTES	Eo, Bs, Mo, actT, NK, iDC, Tm	CCR1, CCR3, CCR4,CCR5	300-06/250-07/400-13
CCL6	(C-10)	Mo	CCR1	250-06
CCL7	MCP-3 (FIC)	Eo, Bs, Mo, actT, NK, iDC	CCR1,CCR2, CCR3	300-17/250-08
CCL8	MCP-2	Eo, Bs, Mo, actT, NK, iDC	CCR1, CCR2B, CCR3, CCR5	300-15/250-14
CCL9/CCL10	(MIP-1γ, MRP-2)	PMN, actT	CCR1	250-12
CCL11	Eotaxin	Eo, Bs, actT [Th2], iDC	CCR3	300-21/250-01
CCL12	(MCP-5)	Eo, Bs, Mo, actT, NK, iDC	CCR2	250-04
CCL13	MCP-4, CKβ-10	Eo, Bs, Mo, actT, NK, iDC	CCR1,CCR2, CCR3	300-24
CCL14	HCC-1	Eo, Mo, T	CCR1,CCR3, CCR5	300-38B/300-38
CCL15	MIP-5, MIP-1d, HCC-2, LKN-1	Mo, T	CCR1, CCR3	300-43
CCL16	LEC, HCC-4	Mo, actT [Th1]	CCR1	300-44
CCL17	TARC (ABCD-2)	actT [Th2]	CCR4	300-30
CCL18	MIP-4, DC-CK1, PARC, AMAC-1	Tr, iDC	unknown	300-34
CCL19	MIP-3β, ELC, Exodus-3, CKβ-11	Tr, actT, mDC	CCR7	300-29B/250-27B
CCL20	MIP-3α, LARC, Exodus-1	Tm, B, iDC, PMN	CCR6	300-29A/250-27
CCL21	Exodus-2, 6Ckine, SLC	Tr, actT, mDC	CCR7	300-35/250-13
CCL22	MDC, STCP-1 (ABCD-1)	Mo, actT [Th2], NK, iDC	CCR4	300-36/300-36A/250-23
CCL23	MIP-3, MPIF-1, CKβ-8	PMN, Mo, Tr	CCR1	300-29
CCL24	Eotaxin-2, MPIF-2, CKβ-6	Eo, Bs, actT [Th2], iDc, PMN, Tr	CCR3	300-33/250-22
CCL25	TECK	Thymocytes, Tr, iDC	CCR9	300-45
CCL26	MIP-4α, Eotaxin-3	Eo, Bs, actT [Th2], iDC	CCR3	300-48
CCL27	CTACK, ILC, Eskine	actT	CCR10	300-54/250-26
CCL28	MEC	actT, Tr, Eo	CCR3, CCR10	300-57/250-30