文章目录[隐藏]
IL5 分子靶点信息概述
- 分子名：IL5, interleukin 5
- 基因家族：Interleukins
- 别名：IL-5; EDF; TRF
- 全称：interleukin-5; T-cell replacing factor; B cell differentiation factor I; eosinophil differentiation factor; colony-stimulating factor, eosinophil; interleukin 5 (colony-stimulating factor, eosinophil)
IL5 分子靶点综述
白细胞介素5(IL-5)是造血家族Th2细胞因子成员，由115个氨基酸组成。与该细胞因子家族其它成员(IL-3和GM-CSF)不同，该糖蛋白的活化形式是同源二聚体。IL-5由Th2细胞和肥大细胞分泌。它对B细胞以及其它类型的细胞产生的生物学活性表明，IL-5对Th2细胞的活性具有重要的功能性作用。IL-5通过与其受体结合，刺激B细胞生长，提高免疫球蛋白分泌。它也是活化嗜酸性粒细胞的关键因子。IL-5一直以来与多种变态疾病相关，包括变应性鼻炎和哮喘，在循环组织、气管组织中观察到大幅增加的IL-5，而痰嗜酸性粒细胞则减少。
IL5, interleukin 5 分子靶点种属信息
人 Human IL5 分子靶点信息
- 分子名：IL5, interleukin 5
- 别称：
- B cell differentiation factor I
- B-cell differentiation factor I
- colony-stimulating factor, eosinophil
- EDF
- eosinophil differentiation factor
- IL-5
- interleukin-5
- T-cell replacing factor
- TRF
- 基因序列：NCBI_Gene: 3567
- 蛋白序列：UniProtKB: P05113
人 Human IL5靶点分子功能（预测）
Predicted to enable cytokine activity; growth factor activity; and interleukin-5 receptor binding activity. Involved in positive regulation of podosome assembly. Located in extracellular region. Implicated in asthma. Biomarker of several diseases, including Churg-Strauss syndrome; Henoch-Schoenlein purpura; arthritis (multiple); asthma (multiple); and lymphoid leukemia (multiple).
小鼠 Mouse Il5 分子靶点信息
- 分子名：Il5, interleukin 5
- 别称：
- Il-5
- 基因序列：NCBI_Gene: 16191
- 蛋白序列：
小鼠 Mouse Il5 靶点分子功能（预测）
Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of immunoglobulin production; and positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).
大鼠 Rat Il5 分子靶点信息
- 分子名：Il5, interleukin 5
- 别称：
- B-cell growth factor II
- BCGF-II
- cytotoxic T-lymphocyte inducer
- eosinophil differentiation factor
- IL-5
- Interleukin 5 (colony-stimulating factor eosinophil)
- Interleukin 5 (colony-stimulating factor, eosinophil)
- interleukin-5
- T-cell replacing factor
- TRF
- 基因序列：NCBI_Gene: 24497
- 蛋白序列：
大鼠 Rat Il5 靶点分子功能（预测）
Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).
