F3/CD142 靶点信息

F3 分子靶点信息概述

  • 分子名：F3, coagulation factor III, tissue factor
  • 基因家族：CD molecules
  • 别名：CD142; TF
  • 曾用名：coagulation factor III (thromboplastin, tissue factor)
  • 全称：tissue factor

F3 分子靶点综述

组织因子（TF），也被称为凝血因子III、F3和CD142，是一种属于组织因子家族的单次跨膜I型膜蛋白。组织因子是参与止血和炎症过程的蛋白质之一。肝脏中活化的单核细胞会增强组织因子的表达，而这些细胞在肝脏中积聚时可能会加剧炎症。组织因子在血管损伤后，通过与血浆中的丝氨酸蛋白酶因子VIIa结合并激活它，从而启动血液凝固系统。组织因子不仅是正常血液凝固的主要生理启动因子，而且在实体恶性肿瘤的自然进程中也起着重要作用——它能够促进肿瘤的转移和血管生成，并介导从外部向内部的信号传导。许多不与血液接触的组织以及其他细胞在受到损伤或激活时也会表达组织因子，这些细胞包括内皮细胞、组织巨噬细胞和外周血单核细胞。凝血因子III是一种跨膜糖蛋白，它将凝血丝氨酸蛋白酶因子VII/VIIa（FVII/VIIa）定位到细胞表面。组织因子的主要功能是激活凝血级联反应。TF与FVIIa形成的复合物还能通过切割一种名为蛋白酶激活受体2（PAR2）的G蛋白偶联受体来激活细胞。肿瘤细胞也会表达组织因子，这会导致多种病理过程的发生，如血栓形成、肿瘤转移、肿瘤生长和肿瘤血管生成。作为止血和血管生成的关键调节因子，组织因子还与多种疾病的病理机制有关，包括心血管疾病、炎症性疾病和肿瘤性疾病。

F3, coagulation factor III, tissue factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human F3 分子靶点信息

  • 分子名：F3, coagulation factor III, tissue factor
  • 别称：
    • CD142
    • coagulation factor 3
    • coagulation factor III (thromboplastin, tissue factor)
    • FLJ17960
    • TF
    • TFA
    • thromboplastin
    • tissue factor
  • 基因序列：NCBI_Gene: 2152
  • 蛋白序列：UniProtKB: P13726

人 Human F3靶点分子功能（预测）

Enables phospholipid binding activity and protease binding activity. Contributes to serine-type endopeptidase activity. Involved in several processes, including acute inflammatory response; positive regulation of endothelial cell apoptotic process; and positive regulation of signal transduction. Acts upstream of or within positive regulation of interleukin-8 production. Located in external side of plasma membrane and extracellular space. Part of serine-type peptidase complex. Implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Biomarker of several diseases, including diabetes mellitus (multiple); diabetic angiopathy; hematologic cancer (multiple); lung disease (multiple); and thrombosis (multiple).

小鼠 Mouse F3 分子靶点信息

小鼠 Mouse F3 靶点分子功能（预测）

Predicted to enable cytokine receptor activity; phospholipid binding activity; and protease binding activity. Predicted to contribute to serine-type endopeptidase activity. Predicted to be involved in several processes, including acute inflammatory response; positive regulation of endothelial cell apoptotic process; and positive regulation of signal transduction. Predicted to act upstream of or within positive regulation of interleukin-8 production. Predicted to be located in external side of plasma membrane; extracellular matrix; and extracellular space. Predicted to be part of serine-type peptidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor).

大鼠 Rat F3 分子靶点信息

大鼠 Rat F3 靶点分子功能（预测）

Enables protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor).

F3 分子产品列表

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