CXCL3 分子靶点信息概述

  • 分子名:CXCL3, C-X-C motif chemokine ligand 3
  • 基因家族:Chemokine ligands
  • 别名:SCYB3; GROg; MIP-2b; CINC-2b
  • 曾用名:GRO3
  • 全称:GRO3 oncogene; chemokine (C-X-C motif) ligand 3

CXCL3 分子靶点综述

CXCL1、CXCL2和CXCL3,分别称为GRO alpha, GRO beta (MIP-2 alpha) 和GRO gamma (MIP-2 beta),是趋化因子的CXC亚家族成员。成熟的CXCL1/2/3蛋白与B型IL-8受体高度亲和结合,是有效的中性粒细胞吸引剂和活化剂。趋化因子主要作用于白细胞,调节其运输。一般来说,趋化因子α家族成员优先趋化并激活中性粒细胞。重组人生长调节致癌基因γ(GRO-γ)是一种7.9kDa蛋白质,由73个氨基酸组成,包括与CXCR1或CXCR2结合的CXC趋化因子家族共有的“ELR”基序。成熟的人CXCL3 (aa 35-107)与小鼠和大鼠CXCL3的氨基酸序列同源性分别为70%和74%。CXCL3通过与CXCR2受体的相互作用,在单核细胞迁移和粘附中起着关键作用。

CXCL3, C-X-C motif chemokine ligand 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL3 分子靶点信息

  • 分子名:CXCL3, C-X-C motif chemokine ligand 3
  • 别称:
    • C-X-C motif chemokine 3
    • chemokine (C-X-C motif) ligand 3
    • CINC-2b
    • GRO-gamma
    • GRO-gamma(1-73)
    • GRO3
    • GRO3 oncogene
    • GROg
    • growth-regulated protein gamma
    • macrophage inflammatory protein 2-beta
    • melanoma growth stimulatory activity gamma
    • MGSA gamma
    • MIP-2b
    • MIP2-beta
    • MIP2B
    • SCYB3
  • 基因序列:NCBI_Gene: 2921
  • 蛋白序列:UniProtKB: P19876

人 Human CXCL3靶点分子功能(预测)

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Located in extracellular space.

小鼠 Mouse Cxcl3 分子靶点信息

小鼠 Mouse Cxcl3 靶点分子功能(预测)

Enables chemokine activity. Involved in neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; and thymus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).

大鼠 Rat Cxcl3 分子靶点信息

  • 分子名:Cxcl3, C-X-C motif chemokine ligand 3
  • 别称:
    • C-X-C motif chemokine 3
    • chemokine (C-X-C motif) ligand 3
    • Cinc-2
    • Cinc2
    • cytokine-induced neutrophil chemoattractant 2
    • cytokine-induced neutrophil chemoattractant-2
    • gene model 1960, (NCBI)
    • Gm1960
    • macrophage inflammatory protein 2-alpha/beta
    • MIP2-alpha/beta
  • 基因序列:NCBI_Gene: 171551
  • 蛋白序列:UniProtKB: Q10746

大鼠 Rat Cxcl3 靶点分子功能(预测)

Enables chemokine activity. Involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).

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