TLR2 靶点信息

TLR2 分子靶点信息概述

  • 分子名：TLR2, toll like receptor 2
  • 基因家族：CD molecules; Toll like receptors
  • 别名：TIL4; CD282
  • 全称：toll-like receptor 2

TLR2 分子靶点综述

Toll样受体2（TLR2）是一种跨膜受体，可在多种细胞类型（包括小胶质细胞，单核细胞，巨噬细胞和树突状细胞）中表达。TLR组成了模式识别受体家族，在先天免疫反应中起着重要作用。。大量的病原体（例如病毒，细菌和真菌）组成性地表达了一套称为病原体相关分子模式（PAMP）的抗突变分子。这些微生物分子标记物可以由蛋白质，碳水化合物，脂质，核酸和/或其组合组成。单个TLR识别不同的病原体相关PAMP，启动信号级联反应，从而促进免疫反应。

TLR2, toll like receptor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TLR2 分子靶点信息

  • 分子名：TLR2, toll like receptor 2
  • 别称：
    • CD282
    • TIL4
    • toll-like receptor 2
    • toll/interleukin 1 receptor-like 4
    • toll/interleukin-1 receptor-like protein 4
  • 基因序列：NCBI_Gene: 7097
  • 蛋白序列：UniProtKB: O60603

人 Human TLR2靶点分子功能（预测）

Enables several functions, including lipopolysaccharide binding activity; peptide binding activity; and peptidoglycan binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and response to molecule of bacterial origin. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is intrinsic component of plasma membrane. Part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Is integral component of plasma membrane. Implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); middle ear disease (multiple); and nose disease (multiple).

小鼠 Mouse Tlr2 分子靶点信息

小鼠 Mouse Tlr2 靶点分子功能（预测）

Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).

大鼠 Rat Tlr2 分子靶点信息

大鼠 Rat Tlr2 靶点分子功能（预测）

Enables lipopeptide binding activity. Involved in several processes, including neurogenesis; positive regulation of interleukin-10 production; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of acute necrotizing pancreatitis; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).

TLR2 分子产品列表

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