TNFRSF8 靶点信息

TNFRSF8 分子靶点信息概述

  • 分子名：TNFRSF8, TNF receptor superfamily member 8
  • 基因家族：CD molecules; Tumor necrosis factor receptor superfamily
  • 别名：KI-1
  • 曾用名：CD30; D1S166E
  • 全称：tumor necrosis factor receptor superfamily, member 8

TNFRSF8 分子靶点综述

白细胞抗原分化簇30(CD30)，也称为肿瘤坏死因子受体超家族成员8 (TNFRSF8)，是一种膜蛋白，属于肿瘤坏死因子受体(TNFR)超家族。CD30蛋白由活化的而非静息的T细胞和B细胞表达。CD30可能在细胞生长和活化淋巴母细胞转化的调控中起作用，并且在人类免疫缺陷病毒复制中也可能起重要作用。TRAF2和TRAF5可以与该受体相互作用，并介导导致NF-κB活化的信号转导。作为细胞凋亡的正向调节剂，CD30蛋白可根据细胞类型诱导细胞死亡或增殖，并表现出可限制自身反应性CD8效应T细胞的增殖潜能并保护人体免受自身免疫。CD30蛋白表达在各种血液系统恶性肿瘤中上调，并且CD30也与慢性炎性疾病患者(如红斑狼疮、哮喘和类风湿关节炎)的白细胞有关。

TNFRSF8, TNF receptor superfamily member 8 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF8 分子靶点信息

  • 分子名：TNFRSF8, TNF receptor superfamily member 8
  • 别称：
    • CD30
    • CD30 antigen
    • CD30L receptor
    • cytokine receptor CD30
    • D1S166E
    • Ki-1
    • Ki-1 antigen
    • lymphocyte activation antigen CD30
    • tumor necrosis factor receptor superfamily member 8
    • tumor necrosis factor receptor superfamily, member 8
  • 基因序列：NCBI_Gene: 943
  • 蛋白序列：UniProtKB: P28908

人 Human TNFRSF8靶点分子功能（预测）

Predicted to enable transmembrane signaling receptor activity. Involved in cellular response to mechanical stimulus; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Located in plasma membrane.

小鼠 Mouse Tnfrsf8 分子靶点信息

小鼠 Mouse Tnfrsf8 靶点分子功能（预测）

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Is expressed in several structures, including adrenal gland; brain; female reproductive system; intestine; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).

大鼠 Rat Tnfrsf8 分子靶点信息

  • 分子名：Tnfrsf8, TNF receptor superfamily member 8
  • 别称：
    • Cd30
    • CD30L receptor
    • lymphocyte activation antigen CD30
    • tumor necrosis factor receptor superfamily member 8
    • tumor necrosis factor receptor superfamily, member 8
    • Tumor necrosis factor superfamily member 8
    • tumor necrosis factor superfamily member CD30
    • tumor necrosis factor superfamily, member CD30
  • 基因序列：NCBI_Gene: 25069
  • 蛋白序列：

大鼠 Rat Tnfrsf8 靶点分子功能（预测）

Predicted to enable transmembrane signaling receptor activity. Involved in positive regulation of NF-kappaB transcription factor activity. Predicted to be located in plasma membrane. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).

TNFRSF8 分子产品列表

TNFRSF8 分子靶点最新资讯