TNFRSF11B 靶点信息

TNFRSF11B 分子靶点信息概述

  • 分子名：TNFRSF11B, TNF receptor superfamily member 11b
  • 基因家族：Tumor necrosis factor receptor superfamily
  • 别名：OCIF; TR1
  • 曾用名：OPG
  • 全称：osteoclastogenesis inhibitory factor; osteoprotegerin; tumor necrosis factor receptor superfamily, member 11b

TNFRSF11B 分子靶点综述

骨保护素(OPG)，又名破骨细胞抑制因子(OCIF)或肿瘤坏死因子受体超家族成员11B(TNFRSF11B)，是一种细胞因子受体，是肿瘤坏死因子受体超家族的成员。OPG通过抑制破骨细胞前体分化为破骨细胞来降低破骨细胞的产量，同样还可调节破骨细胞的体内、体外吸收。重组人OPG特异性作用于骨骼，可增加骨骼矿物质密度和体积。已有研究报道心脏病和严重精神障碍患者的OPG水平是升高的。近年来，研究者们推测OPG可能在骨骼和心血管疾病之间存在关联，特别是与糖尿病患者的心血管风险增加有关。

TNFRSF11B, TNF receptor superfamily member 11b 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF11B 分子靶点信息

  • 分子名：TNFRSF11B, TNF receptor superfamily member 11b
  • 别称：
    • MGC29565
    • OCIF
    • OPG
    • osteoclastogenesis inhibitory factor
    • osteoprotegerin
    • Paget disease of bone 5
    • PDB5
    • TR1
    • tumor necrosis factor receptor superfamily member 11B
    • tumor necrosis factor receptor superfamily, member 11b
  • 基因序列：NCBI_Gene: 4982
  • 蛋白序列：UniProtKB: O00300

人 Human TNFRSF11B靶点分子功能（预测）

Predicted to enable cytokine activity and signaling receptor activity. Predicted to be involved in skeletal system development. Predicted to act upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular space. Implicated in Paget's disease of bone and osteoarthritis. Biomarker of several diseases, including artery disease (multiple); end stage renal disease; hereditary arterial and articular multiple calcification syndrome; lupus nephritis; and type 2 diabetes mellitus.

小鼠 Mouse Tnfrsf11b 分子靶点信息

小鼠 Mouse Tnfrsf11b 靶点分子功能（预测）

Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b).

大鼠 Rat Tnfrsf11b 分子靶点信息

  • 分子名：Tnfrsf11b, TNF receptor superfamily member 11B
  • 别称：
    • MGC93568
    • Opg
    • Osteoprotegerin
    • tumor necrosis factor receptor superfamily member 11B
    • tumor necrosis factor receptor superfamily, member 11b
    • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • 基因序列：NCBI_Gene: 25341
  • 蛋白序列：UniProtKB: O08727

大鼠 Rat Tnfrsf11b 靶点分子功能（预测）

Predicted to enable cytokine activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b).

TNFRSF11B 分子产品列表

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