TIMP2 靶点信息

TIMP2 分子靶点信息概述

  • 分子名：TIMP2, TIMP metallopeptidase inhibitor 2
  • 基因家族：Tissue inhibitor of metallopeptidases
  • 别名：CSC-21K
  • 全称：tissue inhibitor of metalloproteinase 2

TIMP2 分子靶点综述

组织金属蛋白酶抑制因子2 (TIMP2)基因是TIMP基因家族的成员之一。在TIMP家族的四个已知成员中，TIMP-2既具有所有TIMP的共同特征，又具有其自身的独特特征。由该基因家族编码的蛋白质是基质金属蛋白酶(MMP)的天然抑制剂，基质金属蛋白酶是一组参与细胞外基质降解的肽酶。TIMP2既作为MMP抑制剂又起到活化剂的作用。TIMP-1比TIMP-2更好地抑制MMP-7、MMP-9、MMP-1和MMP-3的活性，而TIMP-2则比其他TIMP更有效地抑制MMP-2的活性。 在黑色素细胞中，TIMP2基因的表达可能受MITF的调控。 最近研究发现，TIMP2在海马功能和认知功能中起着重要的作用。

TIMP2, TIMP metallopeptidase inhibitor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIMP2 分子靶点信息

  • 分子名：TIMP2, TIMP metallopeptidase inhibitor 2
  • 别称：
    • CSC-21K
    • DDC8
    • KIAA1731NL
    • metalloproteinase inhibitor 2
    • testicular secretory protein Li 57
    • TIMP-2
    • tissue inhibitor of metalloproteinase 2
    • tissue inhibitor of metalloproteinases 2
  • 基因序列：NCBI_Gene: 7077
  • 蛋白序列：UniProtKB: P16035

人 Human TIMP2靶点分子功能（预测）

Enables peptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in negative regulation of metallopeptidase activity. Located in collagen-containing extracellular matrix. Implicated in Moyamoya disease. Biomarker of several diseases, including Duchenne muscular dystrophy; aortic disease (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and preretinal fibrosis.

小鼠 Mouse Timp2 分子靶点信息

小鼠 Mouse Timp2 靶点分子功能（预测）

Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).

大鼠 Rat Timp2 分子靶点信息

  • 分子名：Timp2, TIMP metallopeptidase inhibitor 2
  • 别称：
    • metalloproteinase inhibitor 2
    • MGC105282
    • TIMP-2
    • tissue inhibitor of metalloproteinase 2
    • tissue inhibitor of metalloproteinases 2
  • 基因序列：NCBI_Gene: 29543
  • 蛋白序列：UniProtKB: P30121

大鼠 Rat Timp2 靶点分子功能（预测）

Enables integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).

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